New Functions of Well-Known Genes in Neurodevelopment and Pathology

Correct brain function relies on the coordinated development and synchronized action of neurons. Over the years, numerous genes have been identified as key players in brain development and pathology. With advances in science and technology, new candidates continually emerge in this field, often drawing focus away from previously discovered genes and limiting further inquiry into their functions and associated pathways. Consequently, many critical studies that deepen our understanding of these established genes and uncover new aspects of their roles are overlooked. Additionally, several genes or pathways previously not linked to disease are now recognized as significant factors in brain dysfunction.This Research Topic aims to shed new light on the cross-regulation of established disease-related signaling pathways and genes in brain development. We seek to provide a comprehensive and nuanced overview of recent discoveries that reveal novel functions of well-known genes in both health and disease. Subtopics of interest include, but are not limited to the following:- Cross-regulation mechanisms among established genes involved in brain development and disease- Previously unrecognized roles of established genes in neurological and psychiatric disorders- Gene-environment interactions impacting brain development and function- Epigenetic and post-transcriptional regulation of established genes involved in neurodevelopment- Translational implications of these genes in therapeutic development for brain disorders Topic editors: Andrzej W Cwetsch, Rui O. Costa, Javier Gilabert-Juan, Sofia Ferreira Source: https://www.frontiersin.org/research-topics/68495/new-functions-of-well-known-genes-in-neurodevelopment-and-pathology