New Technologies and Applications in Oral Disease Models

Oral diseases are a significant global health issue, affecting both quality of life and overall systemic health. Animal models have long played an indispensable role in understanding disease mechanisms and evaluating therapeutic strategies. However, traditional in vivo models struggle to accurately replicate the complexity of the human oral environment, including tissue architecture, microbiome interactions, and immune responses. In recent years, technological innovations such as genetically modified animal models, CRISPR-based gene editing, and high-resolution imaging have greatly advanced preclinical research. These technologies enable precise manipulation and real-time monitoring of disease processes, improving the reliability of experimental outcomes. Furthermore, complementary technologies such as organ-on-a-chip and 3D bioprinting contribute to the development of hybrid platforms that strengthen the bridge between laboratory research and clinical applications.The primary objective of this research is to integrate animal models with cutting-edge technologies to advance oral disease modeling. By utilizing genetic engineering, CRISPR technology, and high-resolution imaging, we aim to develop models that more accurately replicate human oral physiology and pathology. This approach will enable precise analysis of complex interactions among oral tissues, microbiomes, and immune responses. Furthermore, we will create hybrid systems that combine organ-on-a-chip platforms and 3D bioprinting, merging the advantages of in vivo and in vitro methods. Ultimately, the goal is to accelerate drug development for dental treatments and support personalized therapeutic strategies. This research seeks to bridge the gap between preclinical studies and clinical applications, contributing to global progress in the prevention and treatment of oral diseases.This research focuses on the development, validation, and application of advanced animal models for oral disease studies. It also explores hybrid modeling approaches that integrate organ-on-a-chip platforms and 3D bioprinting to replicate oral tissue complexity. Key areas include disease mechanisms, microbiome dynamics, immune responses, and therapeutic evaluation, aiming to improve preclinical predictability and foster innovation in oral health research. We welcome articles addressing, but not limited to, the following themes:• Development and validation of advanced animal models for oral disease research• Genetic engineering and CRISPR-based approaches in oral health studies• High-resolution imaging techniques for real-time disease monitoring• Organ-on-a-chip platforms and their integration with animal models• 3D bioprinting applications for replicating oral tissue complexity• Microbiome dynamics and immune response in oral disease models• Translational strategies bridging preclinical models and clinical applications• Innovative methodologies for drug development and personalized therapies Topic editors: Emi Shimizu, Yoshiyuki Shibukawa Source: https://www.frontiersin.org/research-topics/77166/new-technologies-and-applications-in-oral-disease-models