Novel Biosensing Technologies in Precision Medicine: next-generation platforms and clinical prospects

The field of biomedical sensing is rapidly evolving, driven by the demand for more precise, continuous, and real-time health monitoring as part of precision medicine initiatives. Implantable biosensors, alongside injectable, ingestible, and wearable systems, represent a new frontier in healthcare technology, enabling the direct tracking of physiological and biochemical markers within the human body. Despite notable progress, such as improvements in sensor miniaturization, materials for biocompatibility, and engineering of stable biointerfaces, significant challenges remain related to long-term function, specificity, regeneration, and seamless integration with clinical workflows. Recent studies have demonstrated promising sensing platforms and recognition elements like aptamers, molecularly imprinted polymers, and living cell-based sensors, which provide enhanced selectivity and responsiveness for in vivo applications. However, reliably achieving continuous, selective, and non-invasive biosensing in complex biological environments, and translating these technologies into routine clinical practice, remain outstanding questions. The deployment of these advanced biosensors could revolutionize disease detection, treatment monitoring, and personalized therapy guidance, but further research is necessary to overcome material, technical, and translational barriers.This Research Topic aims to gather cutting-edge research and comprehensive reviews focused on the development and application of implantable, ingestible, injectable, and wearable biosensors for precision medicine. The central objectives are to highlight innovations in sensor design—particularly in optical and electrochemical domains—and to showcase breakthroughs in biorecognition elements that enhance sensitivity, selectivity, and longevity. Special attention will be given to strategies enabling continuous sensing, regeneration, and real-time data capture in biological systems, as well as approaches that demonstrate clear potential for clinical translation and improved patient outcomes.Beyond the scientific and technical challenges, the rise of continuous, long-term biosensing raises pressing questions that extend into the legal, ethical, and social domains. Continuous monitoring technologies — such as glucose sensing for diabetes management — have already shown how transformative long-term monitoring can be for patients, but they have also exposed significant barriers around who owns and controls the resulting data: clinicians, device manufacturers, or the patients themselves. Data security, privacy, and the ethics of data access all shape whether these technologies can be trusted and adopted at scale. Addressing these barriers early, alongside the underlying sensing science, is essential: unresolved data governance issues can otherwise stall investment and slow the translation of promising technologies later in the development pathway.To gather further insights in this domain, we welcome articles addressing, but not limited to, the following themes:• Wireless implantable, injectable, ingestible, and wearable biosensing platforms• Optical and electrochemical transductions• Aptamer-, antibody-, MIP-, and cell-based biosensing• Novel recognition elements for selective and stable biomarker detections• Continuous and regenerable biosensing strategies• Materials and interfaces for long-term implantation and biocompatibility• Biosensors for personalized diagnostics, monitoring, and therapy guidance• Biosensors for digital twins• Translational and clinical applications of implantable biosensing technologies• Data ownership, governance, and access in long-term biosensing — clinician, industry, and patient perspectives• Ethical, privacy, and security considerations in continuous health data collection• Legal and regulatory barriers to patient data access and control, and their impact on technology adoption and investment Topic editors: Abraham Vázquez-Guardado, Daniel Franklin, Ronit Freeman Source: https://www.frontiersin.org/research-topics/81784/novel-biosensing-technologies-in-precision-medicine-next-generation-platforms-and-clinical-prospects