Novel Perspectives in the Medical and Surgical Treatment of Gynecological Malignancies

Two pillars of modern oncology are treatment personalization and the reduction of treatment-related morbidity. Beginning in the early 2000s and continuing over the past two decades, advances in both surgical and medical treatments have reshaped the course of gynecologic malignancies. Where indicated, surgical procedures have shifted from the one-size-fits-all demolitive approach of the last century to personalized, less invasive or minimally invasive approaches and techniques, reducing surgical morbidity without compromising — and in some cases enhancing — oncological outcomes. Similarly, broad-spectrum, highly toxic multi-agent chemotherapeutic regimens have been replaced by well-tolerated chemotherapy combinations, which are now the standard of care for most patients with ovarian, endometrial, cervical, or vulvar cancer. Furthermore, advances in biomedical technologies have deepened the understanding of tumor biology, and the identification of molecular targets has paved the way for personalized, tumor-specific targeted therapies.Perspectives in the medical and surgical treatment of gynecologic malignancies are rapidly evolving, and evidence in the literature is continuously growing. However, gynecologic malignancies remain a major cause of morbidity and mortality worldwide, and many clinical issues remain unsolved, with a non-negligible proportion of patients suffering from treatment-related morbidity and eventually dying of their disease.This Research Topic aims to explore advances in the oncologic treatment of gynecologic malignancies (ovarian, endometrial, cervical, and vulvar cancers), with particular interest in insights into recently developed approaches and research addressing unmet needs. We warmly invite authors to contribute narrative reviews, systematic reviews, meta-analyses, case reports, and original research articles to this article collection.Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal. Topic editors: Tommaso Bianchi, Montassar Ghalleb, Chiara Cassani Source: https://www.frontiersin.org/research-topics/71248/novel-perspectives-in-the-medical-and-surgical-treatment-of-gynecological-malignancies