Nutrition as a Therapeutic Strategy in Metabolic Diseases and Nephropathies

The global rise in obesity and diabetes has led to a parallel increase in CKD and end-stage kidney disease. Metabolic alterations such as insulin resistance, chronic low-grade inflammation, oxidative stress, dyslipidemia, and hypertension contribute to renal microvascular injury and progressive nephron loss. Nutritional factors - including excessive caloric intake, high sodium consumption, ultra-processed foods, altered protein intake, and imbalanced fatty acid profiles - play a critical role in these pathophysiological mechanisms.In patients with established kidney disease, nutritional management becomes even more complex, requiring careful modulation of protein, phosphorus, potassium, sodium, and caloric intake while preventing malnutrition and sarcopenia. Emerging research on gut microbiota, metabolomics, plant-based diets, ketogenic approaches, intermittent fasting, and personalized nutrition highlights the need for updated, evidence-based guidance that bridges general medicine and nephrology.Metabolic disorders - including obesity, type 2 diabetes mellitus, metabolic syndrome, and hypertension - represent leading global health challenges and major risk factors for chronic kidney disease (CKD). Nutrition plays a central role not only in the prevention of these conditions but also in modulating their progression and systemic complications, including nephropathies. However, nutritional management in general medicine and nephrology remains heterogeneous, often lacking integration between metabolic and renal perspectives.This Research Topic aims to provide a comprehensive and translational overview of nutrition as a therapeutic and preventive tool in metabolic diseases and kidney disorders. By integrating evidence from clinical trials, mechanistic studies, epidemiology, and precision medicine approaches, we seek to clarify how dietary interventions can modify cardiometabolic risk, delay kidney damage, and improve outcomes in patients with established nephropathies. The collection will promote multidisciplinary dialogue among internists, nephrologists, endocrinologists, nutrition scientists, and primary care physicians to foster evidence-based, patient-centered nutritional strategies.This Research Topic welcomes original research articles, systematic reviews, meta-analyses, clinical trials, translational studies, brief research reports, and perspectives addressing nutrition in metabolic and renal diseases.Suggested themes include (but are not limited to):Nutritional prevention of metabolic syndrome and CKDDietary patterns (Mediterranean, DASH, plant-based, low-carb, ketogenic, planetary health diet, low-protein diet) in metabolic and renal outcomesProtein intake modulation in CKD and diabetic kidney diseaseNutrition in obesity-related glomerulopathyMicronutrients, sodium, and phosphorus managementGut microbiota and diet–kidney axisInflammation, oxidative stress, and dietary modulationSarcopenia, frailty, and malnutrition in CKDPrecision nutrition and metabolomicsNutritional strategies in dialysis and post-transplant patientsLifestyle medicine approaches integrating diet, physical activity, and metabolic healthWe particularly encourage interdisciplinary contributions that bridge internal medicine and nephrology, as well as studies addressing implementation of nutritional strategies in real-world clinical practice. Topic editors: Guido Gembillo, Luca Soraci, Izabela Zakrocka, Safak Mirioglu Source: https://www.frontiersin.org/research-topics/79762/nutrition-as-a-therapeutic-strategy-in-metabolic-diseases-and-nephropathies