Nutrition, Endocrine Environment, and Human Reproduction: An Integrated Perspective

Reproductive function is tightly linked to metabolic homeostasis, immune balance, and hormonal signaling. Increasing evidence indicates that chronic low-grade inflammation, oxidative stress, and endocrine disruption negatively affect gametogenesis, ovarian reserve, endometrial receptivity, and semen quality. Parallel to these biological processes, modern lifestyles are characterized by suboptimal dietary patterns and widespread exposure to environmental chemicals with endocrine activity.Recent advances have highlighted the role of nutrition and the microbiota as modulators of immune and endocrine function, positioning them as central players in reproductive health. Understanding how these systems interact across the lifespan is essential for addressing fertility decline and improving outcomes in both natural conception and assisted reproduction.The goal of this Research Topic is to address the growing need for an integrated framework that connects nutrition, endocrine regulation, immune function, and environmental exposures in the context of human reproduction. Despite substantial advances in reproductive medicine, fertility disorders continue to rise, suggesting that traditional organ-centered or hormone-focused approaches may be insufficient to fully capture the complexity of reproductive dysfunction. This Research Topic seeks to promote research that elucidates how modifiable lifestyle and environmental factors interact with biological systems to influence reproductive capacity in both women and men. By fostering dialogue across nutrition science, endocrinology, immunology, and reproductive biology, the collection aims to identify shared mechanisms, emerging biomarkers, and novel intervention targets. Ultimately, the objective is to support the development of evidence-based, preventive, and personalized strategies capable of improving reproductive outcomes and long-term health.This Research Topic welcomes original research articles, reviews, mini-reviews, and translational studies addressing the interactions between nutrition, endocrine regulation, immunity, and environmental factors in human reproduction. Topics of interest include, but are not limited to:• Nutritional modulation of ovarian and testicular function.• Inflammation, oxidative stress, and reproductive outcomes.• Endocrine-disrupting chemicals and reproductive health.• Diet, metabolism, and fertility-related disorders.• Gut and genital microbiota in female and male reproduction.• Nutritional and lifestyle interventions in natural and assisted reproduction. Both human and relevant experimental studies are encouraged, with a particular emphasis on integrative and multidisciplinary approaches. Topic editors: Veronica Corsetti, Annalisa Liprino Source: https://www.frontiersin.org/research-topics/76770/nutrition-endocrine-environment-and-human-reproduction-an-integrated-perspective