Periodontitis and Systemic Disease: Epidemiological Evidence, Biological Pathways, and Clinical Implications

Periodontitis is increasingly recognised not as an isolated oral condition but as a significant contributor to systemic disease burden. Yet the epidemiological evidence linking periodontal status to conditions such as cardiovascular disease, diabetes, stroke, and cognitive decline remains fragmented across populations, study designs, and biological frameworks.This Research Topic aims to consolidate and advance the global evidence base on the periodontal-systemic relationship. We invite submissions that explore epidemiological associations, shared risk factor models, inflammatory and microbiological mechanisms, and the clinical and public health implications of treating periodontitis in systemically compromised patients. We particularly welcome studies that draw on large population datasets, longitudinal cohorts, and multi-country comparisons to strengthen the quality and generalisability of existing evidence.We invite original research, systematic reviews, meta-analyses, and perspective articles addressing:- Epidemiological associations between periodontitis and systemic conditions (cardiovascular, metabolic, neurological, respiratory)- Shared biological pathways: inflammation, dysbiosis, and immune modulation- Regional and global burden of periodontitis and its systemic implications- Periodontal treatment as a modifier of systemic disease risk and outcomes- Comorbidity patterns and multi-disease clustering in population studies- Methodological advances in periodontal-systemic epidemiology Topic editors: Yago Gecy De Sousa Né, Benso Sulijaya Source: https://www.frontiersin.org/research-topics/82560/periodontitis-and-systemic-disease-epidemiological-evidence-biological-pathways-and-clinical-implications