Pharmacological Approaches Targeting Neutrophils, Platelets, and Neutrophil-Platelet communication in Inflammation: Volume III

This topic is part of a series: Pharmacological Approaches Targeting Neutrophilic Inflammation: Volume II.Neutrophils (or polymorphonuclear leukocytes, PMNL) are the most numerous white blood cells that perform vital functions in the innate immune system. Neutrophils can combat pathogens and eliminate infections through a variety of means, including phagocytosis, production of reactive oxygen species, degranulation of microbicidal molecules, and formation of neutrophil extracellular traps. When neutrophils are unable to engulf a pathogen, they begin to surround it for further destruction. A swarm of neutrophils effectively destroys bacterial clusters or fungal hyphae. Neutrophils communicate with each other and enhance their power through collective behavior – swarming. Collective behavior of eukaryotic cells is often based on self-organization processes. Lipoxygenases are known to generate oxylipins involved in intercellular signaling and cell-cell communication. The production of chemoattractant leukotriene B4 by neutrophils themselves contributes to this self-organization. Neutrophils communicate with other cells, in particular, with platelets, and neutrophil recruitment depends on neutrophil-platelets interaction. Molecular mechanisms controlling these processes are not fully understood. The orchestration of platelets-bacteria-leukocytes interaction is critical for correct immune responses and a very important therapeutic pharmacological target. Pharmacological interventions at all stages of neutrophil activation and neutrophil-platelet interactions may be beneficial in combating various inflammatory diseases. The ability of neutrophils to regulate inflammatory and immune responses depends on the release of molecules produced by neutrophils. During the inflammatory response, neutrophils are recruited to sites of inflammation, initiating the generation and release of oxidants and proteases they produce, playing a crucial role both in the inflammatory response itself and in its resolution. Pharmacological interventions targeting their synthesis and release are of particular interest. Approaches targeting neutrophil interactions with bacteria and neutrophil-platelets interaction and modulating neutrophil responses are also relevant. This Research Topic aims to explore the complex interplay between immune cells to provide deeper understanding of collective cellular behavior and encourage the development of new therapeutic approaches that will target immune responses to pathogen invasion.To gain further insights into the field of collective cell behavior, we welcome manuscripts that address, among other topics, the following:• Collective cell behavior and chemoattractant leukotriene B4 synthesis by neutrophils• Mechanisms of swarm initiation, amplification and resolution• Regulation of neutrophil-platelet communication• Role of platelets in sensing bacteria by neutrophils• Oxidative stress as a key factor in cell-pathogen interactions, and pharmacological approaches to modulate red/ox status in bacteria-leukocytes and in platelets-bacteria-leukocytes interaction• Mechanisms of eicosanoid synthesis at increasing bacteria load and increasing size of pathogen Topic editors: Galina Sud’ina, Alexey Victorovich Sokolov, Roman A. Zinovkin, Boris Victor Chernyak, Tsong-Long Hwang Source: https://www.frontiersin.org/research-topics/80198/pharmacological-approaches-targeting-neutrophils-platelets-and-neutrophil-platelet-communication-in-inflammation-volume-iii