Physiology of Tele-Exercise and Sensor-Guided Training Across the Health–Disease Continuum

Regular exercise is a cornerstone in the prevention and management of chronic cardiometabolic, respiratory, oncological, musculoskeletal, and mental health conditions. In parallel, tele-exercise and telerehabilitation programmes, along with sensor-guided and app-based training solutions, are rapidly expanding and enabling remote delivery, monitoring, and personalisation of exercise in real-world settings. Despite the growing uptake of these digital modalities, the acute responses and chronic physiological adaptations they elicit, and the mechanisms driving inter-individual variability, remain incompletely understood.Key questions are still open: How should training load, intensity distribution, and progression be optimised when exercise is delivered remotely rather than under traditional face-to-face supervision? Which neuromuscular, cardiorespiratory, autonomic, endocrine, inflammatory, or neurotrophic responses best predict successful adaptation across clinical populations and along the prevention-to-well-being spectrum? How can data from wearables and other sensors (e.g., heart rate and variability, inertial measurement units, smart textiles, sleep and recovery indices) be integrated into decision-support systems that individualise exercise dose, minimise non-response, and reduce the risk of adverse events; particularly in people living with complex chronic conditions?This Research Topic aims to bring together cutting-edge work on the physiological responses to digitally supported, remotely delivered, and sensor-guided exercise interventions. We welcome submissions including, but not limited to: (i) tele-exercise and telerehabilitation programmes with detailed physiological outcomes in clinical populations; (ii) sensor-guided and app-based exercise interventions focusing on physiological mechanisms and adaptations; (iii) integration of wearable and remote-monitoring technologies into exercise prescription, load management, and recovery strategies; (iv) methodological and validation studies on physiological signal acquisition and processing in free-living and tele-exercise contexts; (v) trials and implementation studies comparing tele-exercise, hybrid, and centre-based models with comprehensive physiological profiling; and (vi) systematic reviews, meta-analyses, and perspectives that synthesise current evidence and outline future directions for exercise-based digital therapeutics.By consolidating knowledge across the health-disease continuum, this Topic seeks to inform more precise, safe, and scalable exercise prescriptions supported by digital and sensor-based technologies. Topic editors: Pedro Morouço, Silvia Fantozzi Source: https://www.frontiersin.org/research-topics/78526/physiology-of-tele-exercise-and-sensor-guided-training-across-the-health-disease-continuum