Quantum Electromagnetic Photon-Mediated Communication in Neuronal Networks — Volume II

Neuroscience has traditionally explained communication in the brain through electrochemical signaling: action potentials, synapses, neuromodulators, and network dynamics. In parallel, a growing body of interdisciplinary work has raised a provocative set of questions: could electromagnetic field dynamics and photon-related phenomena contribute to neural signaling or coordination, beyond what is captured by standard biochemical and electrophysiological descriptions? This includes research on ultraweak photon emission (often discussed as “biophotons”), endogenous electromagnetic fields generated by neural populations, and theoretical proposals in which coherent or structured fields could influence neural processing.The first volume of this Research Topic here. helped consolidate early perspectives in a field that remains scientifically exciting—and actively debated. A key challenge is that many candidate effects are subtle, measurement-sensitive, and easy to misinterpret without careful controls. As a result, the field’s progress depends on moving from general possibility statements toward quantitative, reproducible evidence and mechanistic hypotheses with explicit, falsifiable predictions.Volume II aims to advance the topic from “signals and speculation” to mechanisms and decisive tests. We invite contributions that improve experimental rigor, define clear boundary conditions for competing hypotheses (what should be observable, when, and at what magnitude), and connect physics-based models to biological plausibility. Importantly, we also encourage well-designed studies that report null results or limiting constraints, when they meaningfully narrow the hypothesis space and improve standards for future work.This volume is intended as a platform for constructive convergence across quantum physics, biophysics, neuroengineering, and systems neuroscience—supporting both foundational understanding and carefully grounded translational possibilities.We welcome articles addressing, but not limited to, the following:• Measurement and reproducibility• Instrumentation, calibration, shielding, spectral/temporal characterization, and robust statistical pipelines• Protocols and standards for separating biological signals from environmental noise and detector artifacts• Cross-lab validation efforts and reproducibility studies• Biophotons / ultraweak photon emission in neural systems• State dependence (e.g., vigilance, stimulation, pathology), spatial localization, and physiological correlates• Links to metabolism, oxidative stress, redox biology, and mitochondrial dynamics• Mechanistic interpretation of photon emission in neural tissue• Electromagnetic field interactions and coupling mechanisms• Endogenous fields, ephaptic interactions, membrane and ionic mechanisms, and network-level effects• Frequency-specific hypotheses with realistic parameter regimes and predicted effect sizes• Comparative analyses that distinguish classical field effects from quantum-relevant claims• Spin chemistry and magnetic-field effects• Radical-pair–related hypotheses and biologically plausible amplification pathways• Experimental designs that can discriminate among candidate mechanisms• Candidate waveguides, resonances, and structured media• Microtubules, membranes, myelin, extracellular space, and other proposed guiding/resonant structures• Models that include realistic losses, noise sources, and temperature constraints• Predictions that can be tested with imaging, spectroscopy, or perturbation• Theory, modeling, and falsifiable predictions• Biophysically grounded computational models of field- or photon-mediated dynamics• Benchmarks, open datasets, and shared evaluation protocols• Explicit “critical tests” that would support or rule out specific mechanisms• Neurotechnology and translational directions (hypothesis-driven)• Imaging, sensing, and stimulation concepts connected to validated observables• Safety, ethics, and responsible communication of high-uncertainty findings Topic editors: Aristide Dogariu, Marco Pettini, Marco Cavaglià, Travis John Adrian Craddock Source: https://www.frontiersin.org/research-topics/78916/quantum-electromagnetic-photon-mediated-communication-in-neuronal-networks---volume-ii