Regulation of Gene Expression by RNA Processing Steps in Cancers

In higher eukaryotes, a vast variety of RNAs is transcribed from genomic DNA. These transcripts undergo RNA processing steps — splicing, capping, polyadenylation, editing, and modification — to produce mature mRNAs and non-coding RNAs. Splicing includes constitutive and alternative splicing, and around 95% of human genes undergo alternative splicing. Defects in RNA processing are increasingly linked to human disease, including cancers and immunological disorders. Numerous mutations in splicing factors have been reported in cancers and hematological diseases such as myelodysplastic syndrome and leukemia, and dysregulated RNA processing is also implicated in immune cell differentiation and autoimmune/immune-mediated disease. However, the full picture of this regulation and the molecular mechanisms driving disease onset remains to be elucidated.We invite researchers working on RNA processing in gene expression in higher eukaryotes to submit their studies. The scope of this Research Topic is not limited to basic mechanistic research; clinical and translational approaches to therapies for cancers and immunological diseases arising from RNA processing dysregulation are also welcome. The goal of this Research Topic is to explore gene expression mechanisms through RNA processing in cancer and immune-related disease, and the development of therapeutic strategies targeting RNA processing pathways.We accept original research, reviews/mini-reviews, perspectives/opinions, and methodology articles on:1. Dysregulation of RNA splicing in cancer and immunological disease2. Mutations in non-coding RNAs and/or RNA processing factors in cancer and immune-related disease3. Therapeutic approaches for cancer and immunological diseases via modulation of RNA processing pathways Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic. Topic editors: Naoyuki Kataoka, Kenji Ohe Source: https://www.frontiersin.org/research-topics/71183/regulation-of-gene-expression-by-rna-processing-steps-in-cancers