Reimagining Therapeutic Discovery: Structural Biology's Role in Combatting Infectious Diseases

This Research Topic envisions the future of structural biology in infectious disease therapeutic discovery. It explores the potential of cutting-edge methodologies and technologies, such as advanced molecular imaging and high-throughput structural analysis, to revolutionize the identification of novel therapeutic targets. The discussion includes using AI-driven tools and chemical biology approaches to design and engineer proteins and enzymes for targeted drug development. By focusing on infectious and emerging diseases, including malaria, trichomoniasis, schistosomiasis and onchocerciasis, the study outlines how structural tools could lead to groundbreaking discoveries and innovations in treating infectious diseases, fulfilling sustainable health and well-being goals.The goals of this Research Topic are as follows:1) Advance Structural Biology in Therapeutic DiscoveryPromote the use of structural biology to revolutionize the identification of therapeutic targets for infectious diseases.2) Leverage Cutting-Edge TechnologiesIntegrate advanced molecular imaging and high-throughput structural analysis to improve target discovery.3) Implement AI and Chemical Biology ApproachesUtilize AI-driven tools and chemical biology to design and engineer proteins and enzymes for precision drug development.4) Focus on Neglected and Emerging DiseasesApply structural biology tools to address infectious diseases, notably neglected and emerging diseases such as malaria, trichomoniasis, schistosomiasis, and onchocerciasis.5) Drive Innovation in Infectious Disease TreatmentEnable groundbreaking discoveries in infectious disease therapeutics using structural biology insights.6) Support Global Health and SustainabilityContribute to achieving sustainable health and well-being goals through innovative biomedical research.We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:• Structure-based drug discovery for infectious diseases• Structural vaccinology for infectious diseases• Emerging tools for infectious disease therapeutics discovery• Structure-based drug repurposing Topic editors: Oluwatoyin Ajibola Asojo, Tawanda Zininga, Emmanuel Nji, Graham Chakafana Source: https://www.frontiersin.org/research-topics/72843/reimagining-therapeutic-discovery-structural-biologys-role-in-combatting-infectious-diseases