Retinal Cell-State Transitions for Repair and Disease: Reprogramming, Organoids, and Single-Cell Profiling

Retinal repair and vision restoration depend on understanding how retinal cell identities are established, maintained, and re-entered during development, injury response, regeneration, and stem cell-based differentiation. Across systems, these outcomes hinge on transitions between cell states, progenitor-like programs, lineage commitment, stress-adaptive responses, and maturation, shaped by transcriptional and epigenetic regulation.This Collection will bring together work at the intersection of retinal regeneration/reprogramming, human pluripotent stem cell (PSC)-derived retinal organoids, and high-resolution cell-state profiling. We welcome submissions that define and compare retinal cell states across development, injury models, and in vitro differentiation, and that identify mechanisms that enable (or constrain) regenerative competence and functional maturation.Topics of interest include (but are not limited to): endogenous retinal regeneration and RPE reprogramming; transcriptional and epigenetic control of fate transitions (chromatin accessibility, DNA methylation, histone modifications); generation, benchmarking, and maturation of PSC-derived retinal organoids and retinal cell types; single-cell and spatial approaches to map trajectories; microenvironmental/ECM cues; and translational studies connecting cell-state control to retinal degeneration and repair strategies. Topic editors: AGUSTIN LUZ MADRIGAL, Darin Zerti Source: https://www.frontiersin.org/research-topics/77792/retinal-cell-state-transitions-for-repair-and-disease-reprogramming-organoids-and-single-cell-profiling