Rewiring the Cancer Cell: Metabolic Networks Driving Tumor Plasticity, Immune Evasion, and Therapeutic Resistance

Metabolic reprogramming is a fundamental hallmark of cancer, directly influencing tumor cell plasticity, immune evasion, and resistance to anti-cancer therapies. To sustain uncontrolled proliferation, survive in hostile microenvironments, and escape therapeutic pressure, cancer cells undergo profound metabolic adaptations that go far beyond the classical Warburg effect.It is now well established that tumor metabolism forms a dynamic and complex network of bioenergetic and biosynthetic processes, involving mitochondrial function, lipid and amino acid metabolism, redox homeostasis, and close communication with the tumor microenvironment and the immune system. These metabolic changes not only provide proliferative and survival advantages but also contribute to tumor heterogeneity, phenotypic plasticity, metastasis, and resistance to both conventional and targeted therapies.This Research Topic aims to gather innovative studies that deepen our understanding of these interconnected metabolic networks in cancer, highlighting regulatory mechanisms, clinical implications, and their potential as emerging therapeutic targets.We welcome Original Research, Systematic Reviews, Mini Reviews, and Brief Research Reports that explore the diverse roles of metabolic networks in cancer biology, immune modulation, tumor adaptability, and therapeutic resistance. Topic editors: Virginia Márcia Concato-Lopes, Bruna Taciane Da Silva Bortoleti, Fábio Seiva Source: https://www.frontiersin.org/research-topics/72448/rewiring-the-cancer-cell-metabolic-networks-driving-tumor-plasticity-immune-evasion-and-therapeutic-resistance