Role of Short-Chain Fatty Acids in Inflammation and Immune Function

Short-chain fatty acids (SCFAs)—including acetate, propionate, and butyrate—are microbial metabolites produced in the gut through the fermentation of partially digested and indigestible polysaccharides. These metabolites are found in high concentrations in the intestinal tract and serve as essential mediators of communication between the gut microbiota and the host immune system.SCFAs play pivotal roles in modulating innate immune cells such as macrophages, neutrophils, and dendritic cells, thereby shaping early immune responses. In addition, SCFAs influence adaptive immunity by regulating the differentiation and function of T and B lymphocytes, ultimately modulating antigen-specific responses. These immunomodulatory effects are mediated through multiple mechanisms, including HDAC inhibition, GPR signaling, acetyl-CoA metabolism, and broader metabolic reprogramming within immune cells. Given their central role in immune regulation and homeostasis, SCFAs are increasingly recognized as key metabolic biomarkers associated with immune-related and inflammatory diseases.We welcome Original Research Articles, Review articles, and Mini Reviews on topics including, but not limited to:• Mechanistic studies on the role of SCFAs in regulating immune responses and inflammation.• SCFA-based biomarkers for disease diagnosis, progression, and therapeutic response.• Preclinical or clinical studies investigating microbiota-SCFA interactions in immune and inflammatory outcomes.• Bioinformatics and systems biology approaches to elucidate microbiota-SCFA-immune system networks.• Effects of natural products or herbal formulas on gut microbiota composition and SCFA production.• Translational research on microbiota-targeted therapies involving SCFAs. Topic editors: Weicheng Hu, Demin Cai, Honggang Wang, Wei Zhou, Hongxun Tao Source: https://www.frontiersin.org/research-topics/72271/role-of-short-chain-fatty-acids-in-inflammation-and-immune-function