Salivary Gland Tumors: Emerging Concepts in Diagnosis, Biology and Treatment

Salivary gland tumors (SGTs) comprise a rare and heterogeneous group within head and neck oncology, featuring over 20 distinct histological subtypes that differ significantly in their biological behavior and prognosis. The complexity of SGTs arises from their morphological diversity and often overlapping histopathological features, which, combined with unpredictable clinical trajectories, pose considerable diagnostic and therapeutic dilemmas. Recent years have seen intense research focusing on the molecular underpinnings of SGTs, leading to the identification of unique genetic alterations and refined classification systems. Simulation and clinical studies have further highlighted the substantial potential for personalized, biology-driven management. Notably, technological advancements in radiology, digital pathology, and artificial intelligence are transforming both the precision and scope of tumor assessment and risk stratification. Nevertheless, despite these advances, the translation of this knowledge into routine clinical pathways is incomplete. Surgery and radiotherapy remain the backbone of treatment, while systemic therapies, especially for advanced cases, demonstrate variable efficacy. Precision oncology, biomarker discovery, and immunotherapeutics are emerging as hopeful prospects, yet widespread integration into practice lags behind.This Research Topic aims to provide a comprehensive and multidisciplinary forum for the latest developments in the diagnosis, molecular characterization, and management of salivary gland tumors. It seeks to address key questions such as how novel biomarkers, imaging modalities, and molecular insights can be leveraged to refine diagnostic algorithms, personalize therapy, and improve patient outcomes. By fostering collaboration across pathology, radiology, surgical oncology, medical oncology, and translational research, the initiative will highlight critical advances and unresolved clinical questions. The ultimate goal is to synthesize emerging evidence to support integrative strategies and delineate future research priorities for SGTs.While the Research Topic encompasses all aspects of SGT diagnosis and treatment, it places particular emphasis on translational science and clinical innovation. Submissions are encouraged that explore the practical applications and limitations of recent discoveries as well as the challenges of standardizing new approaches. To gather further insights in the evolving field of salivary gland tumor research and clinical management, we welcome articles addressing, but not limited to, the following themes:- Advances in histopathological classification and molecular diagnostics.- Genomic profiling, next-generation sequencing, and gene fusion discoveries.- Prognostic and predictive biomarkers for stratification and monitoring.- Innovations in imaging, radiomics, and artificial intelligence applications.- Surgical techniques emphasizing function preservation and minimally invasive approaches.- Emerging systemic therapies, including targeted agents and immunotherapies.- Strategies for recurrent and metastatic disease management.- Clinical trials and real-world evidence integration.- Quality of life, survivorship, and long-term outcomes.- Translational research bridging laboratory discoveries with patient care.Please note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope of this Research Topic. Topic editors: Giovanni Cammaroto, Mazzola Francesco, Mateusz Szewczyk Source: https://www.frontiersin.org/research-topics/79564/salivary-gland-tumors-emerging-concepts-in-diagnosis-biology-and-treatment