Sepsis and Septic Shock in Companion Animals: Early Recognition, Biomarkers, and Outcomes

Sepsis and septic shock remain among the most challenging and highest-mortality presentations in veterinary emergency and critical care. Despite growing awareness, the field still lacks consensus on definitions, reliable early-warning biomarkers, and evidence-based resuscitation strategies for dogs, cats, and other companion species. This Research Topic aims to consolidate current knowledge and drive new evidence on the recognition, diagnosis, and management of sepsis across the critical-care continuum.We welcome Original Research, Clinical Trials, Systematic Reviews, Reviews, Mini Reviews, Methods, and high-quality Case Reports and Case Series addressing, but not limited to: pathophysiology of sepsis and the host response; diagnostic and prognostic biomarkers (e.g., lactate, C-reactive protein, procalcitonin, cytokines); sepsis scoring systems and early-warning tools; fluid resuscitation, vasopressor and inotrope strategies; source control and antimicrobial stewardship; sepsis-associated organ dysfunction (coagulopathy, acute kidney injury, myocardial dysfunction); nutritional and supportive care; and long-term outcomes and quality of life in survivors. Studies with a One Health perspective and those advancing responsible antimicrobial use are particularly encouraged, in line with SDG 3 (Good Health and Well-being). Topic editors: Massimo Giunti Source: https://www.frontiersin.org/research-topics/84069/sepsis-and-septic-shock-in-companion-animals-early-recognition-biomarkers-and-outcomes