Skeletal Muscle Dysfunction and Insulin Resistance in Diabetes

Skeletal muscle plays an important role in glucose regulation, physical function, and overall metabolic health. In diabetes, impaired insulin action within skeletal muscle can contribute not only to reduced glucose disposal but also to broader changes in muscle quality, function, and adaptability.Skeletal muscle dysfunction in diabetes is influenced by interconnected metabolic, cellular, and physiological processes. Disturbances in insulin signalling, mitochondrial function, substrate utilization, inflammation, and tissue composition may collectively contribute to declining muscle performance and worsening glycaemic control. These changes may become particularly relevant with disease progression, aging, physical inactivity, and the development of diabetes-related complications.This Research Topic aims to bring together studies investigating the mechanisms and consequences of skeletal muscle dysfunction and insulin resistance in diabetes, as well as approaches that may preserve muscle health and improve insulin sensitivity.Topics of interest include, but are not limited to:• Mechanisms of skeletal muscle insulin resistance and impaired glucose uptake in diabetes• Insulin signalling and glucose transport in skeletal muscle• Changes in muscle mass, strength, quality, and physical function in diabetes• Mitochondrial dysfunction and impaired metabolic flexibility• Glucotoxicity, lipotoxicity, oxidative stress, and inflammation in skeletal muscle• Alterations in skeletal muscle glucose and lipid metabolism• Interactions between skeletal muscle dysfunction, aging, and diabetes progression• Exercise, nutritional, and pharmacological interventions• Emerging biomarkers and therapeutic targets for improving muscle health and insulin sensitivity Topic editors: Natasha Jaiswal, Amit Kumar Rai Source: https://www.frontiersin.org/research-topics/84537/skeletal-muscle-dysfunction-and-insulin-resistance-in-diabetes