Smart Hydrogels: Nanostructured Materials for Tissue Engineering and Regenerative Medicine

Hydrogels engineered at the nanoscale are transforming how we design materials that interact with living systems. By combining tunable mechanical properties, stimuli-responsive behavior, and biomimetic architectures, nanostructured hydrogels are enabling new strategies for tissue repair, regeneration, and the broader interface between synthetic materials and biology.This Research Topic welcomes contributions spanning the design, synthesis, characterization, and application of smart and nanostructured hydrogels across tissue engineering, regenerative medicine, and closely related fields. We invite work on, but not limited to:Synthesis and functionalization of nanostructured or composite hydrogelsStimuli-responsive (“smart”) hydrogel systems (thermo-, pH-, light-, magnetically-responsive)Hydrogel scaffolds for tissue and organ regeneration3D/4D bioprinting of hydrogel-based constructsHydrogel platforms for controlled and targeted drug deliveryHydrogel-based biosensors and diagnostic devicesMechanobiology and cell-material interactions within hydrogel matricesSustainable, biobased, or biodegradable hydrogel materialsTranslational and clinical perspectives on hydrogel therapeuticsBy bridging materials chemistry, nanotechnology, and biomedical engineering, this collection aims to advance the fundamental understanding and practical deployment of smart hydrogels, fostering dialogue between researchers working on regenerative applications and those in adjacent domains such as drug delivery, diagnostics, and sustainable materials design. Topic editors: Marta Madaghiele, Laura Blasi, Christian Demitri, Huinan Hannah Liu Source: https://www.frontiersin.org/research-topics/72429/smart-hydrogels-nanostructured-materials-for-tissue-engineering-and-regenerative-medicine