Stem Cell Models for CNS Injury, Regeneration, and Disease

This Research Topic focuses on stem and progenitor cell-based approaches to studying central nervous system (CNS) development, injury, and disease, with particular emphasis on human neuron biology as a core model system. Contributions are welcome on developmental mechanisms, lineage specification, differentiation, maturation, and circuit integration, as well as patient-specific disease modeling in the context of neurodevelopmental disorders.The topic welcomes studies using human pluripotent stem cells, induced pluripotent stem cells, organoid systems, and related advanced in vitro and in vivo models to investigate the molecular, cellular, and functional basis of CNS development, injury, and dysfunction across cell types. Contributions exploring transcriptional, epigenetic, and regulatory mechanisms underlying neural cell identity, maturation, and dysfunction are also highly relevant.In addition, the topic leans into regenerative medicine and repair-oriented perspectives, including stem/progenitor cell-based strategies with potential relevance to CNS injury repair and functional restoration. We would also be glad to consider work at the interface of neural development with endothelial biology, tissue regeneration, and cell-based therapeutic approaches, where these provide mechanistic insight into human neurodevelopment, disease, or future regenerative applications. Topic editors: KOMAL KAUSHIK, Govindaiah Vinukonda Source: https://www.frontiersin.org/research-topics/87156/stem-cell-models-for-cns-injury-regeneration-and-disease