Stochastic Dynamics and Nonequilibrium Thermodynamics in Nonlinear Complex Systems: From Fundamental Physics to Bioengineering Applications

The study of stochastic dynamics in nonlinear systems is a rapidly evolving domain that bridges theoretical physics, environmental dynamics, and bioengineering. Complex systems inherently exhibit randomness driven by microscopic fluctuations, environmental variability, and nonlinear interactions. Principles of nonequilibrium thermodynamics and entropy generation provide a rigorous physical framework to understand how such open systems maintain dynamical stability, dissipate energy, and transition between states far from equilibrium. Applying this thermodynamic lens is essential for deciphering the physical constraints governing fluctuation-driven processes—from transport and pattern formation in soft and environmental matter to nonlinear biological and ecological networks where noise plays a pivotal, constructive role.GoalThis Research Topic aims to advance the integration of stochastic dynamics and nonequilibrium thermodynamics to elucidate the stability, transitions, and energetic constraints of nonlinear systems. Specifically, it seeks to explore how internal fluctuations and external noise impact system behaviour through the quantitative analysis of entropy production, thermodynamic irreversibility, and fluctuation relations. By combining analytical theory, computational modelling, and experimental validation, the objective is to establish generalized frameworks that capture the interplay between stochasticity and thermodynamic constraints. Grounding these methods in fundamental physical principles will enhance predictive capabilities across complex nonlinear phenomena, providing new insights into physical systems and informing robust design principles for microbial ecosystems, bioprocesses, and biotechnological innovations.Scope and Information for AuthorsThis Research Topic invites contributions that advance the physical understanding and methodological development of stochastic dynamics and nonequilibrium thermodynamics in nonlinear systems. We particularly welcome works that develop theoretical frameworks or computational techniques and demonstrate their utility across physical, ecological, or bioengineering domains.Topics of interest include, but are not limited to:-Quantitative analysis of entropy generation and energy dissipation in open, nonlinear systems far from equilibrium-Fluctuation theorems, thermodynamic uncertainty relations, and noise-induced transitions in complex dynamics-Stochastic modelling of nonlinear dynamics under fluctuating environmental conditions-Nonequilibrium thermodynamic frameworks applied to collective behavior, pattern formation, and environmental processes-Cross-disciplinary applications of stochastic thermodynamics to biological systems, including microbial consortia, metabolic pathways, and cellular decision-making-Thermodynamic optimization and noise-mitigation strategies in bioprocesses, bioreactors, and bio-inspired engineered systemsManuscripts may be original research articles, comprehensive reviews, or theoretical perspectives. Contributions should emphasize the underlying physical, mathematical, or thermodynamic principles governing system behavior. Authors are encouraged to showcase how stochastic physics and thermodynamic modeling provide a unifying quantitative foundation for understanding adaptability, resilience, and function in complex living and non-living systems alike. Topic editors: Umberto Lucia, Giulia Grisolia Source: https://www.frontiersin.org/research-topics/87035/stochastic-dynamics-and-nonequilibrium-thermodynamics-in-nonlinear-complex-systems-from-fundamental-physics-to-bioengineering-applications