Sustainable Bio-based Nanocomposites - From Green Synthesis to AI-assisted 4D Design for Advanced Biomedical Engineering

The field of sustainable bio-based nanocomposites has witnessed a surge of innovative research at the intersection of green chemistry, advanced materials science, and biomedical engineering. Amid escalating environmental concerns and the imperative for sustainable materials, bio-derived polymers and nano-reinforcements sourced from biomass, agricultural residues, and industrial by-products have emerged as vital alternatives for the development of functional biomaterials. Green synthesis methods, including enzyme-catalyzed approaches and circular economy frameworks, are increasingly recognized for their potential to transform bio-waste into high-value nanocomposites. Recent studies have explored functionalization techniques to achieve tailored mechanical, thermal, and stimuli-responsive properties, while also delving into the intricate nano-bio interface, protein corona formation, and the associated challenges in toxicity and immunological responses. Despite these strides, existing research continues to grapple with translational bottlenecks, the complexity of biological interactions, regulatory uncertainty, and the need for enhanced computational modeling to foresee and optimize functional outcomes.This Research Topic aims to advance the understanding and technological application of sustainable bio-based nanocomposites, with a particular focus on their role in next-generation biomedical solutions. The objectives include elucidating green synthesis pathways, exploring waste-to-wealth strategies, engineering structural and functional interfaces, and integrating artificial intelligence and 4D bioprinting to achieve precision and responsiveness in medical devices, tissue engineering, and nanomedicine. Key questions revolve around how eco-friendly nanocomposites can be designed for improved biocompatibility, functionality, and clinical translation, and how computational and AI-driven tools can accelerate performance prediction, safety assessment, and regulatory compliance. The anticipated outcome is a roadmap bridging fundamental discoveries and industrial-scale applications for sustainable innovation in biomedicine.The scope of this Research Topic encompasses the design, synthesis, functionalization, characterization, and biomedical deployment of sustainable bio-based nanocomposites, while acknowledging challenges in regulation, commercialization, and societal acceptance. Manuscripts may include fundamental, applied, and translational research around eco-friendly nanocomposites addressing the following themes:• Green synthesis methodologies, circular economy, and waste valorization strategies for bionanocomposites• Structure-activity relationship, interfacial dynamics, and functionalization techniques• Biomedical precision applications: drug delivery, biosensing, antimicrobial/antiviral agents, and theranostics• Regenerative medicine and tissue engineering: scaffold design, stem cell interactions, and controlled release mechanisms• AI-driven computational modeling, machine learning for nano-bio interactions, digital twins, and data analytics• 4D bioprinting, smart and stimuli-responsive systems for dynamic biomedical platforms• Translational barriers, regulatory frameworks, industry collaborations, and sustainability perspectives• Ethical, societal, and long-term innovation considerations in biomedical engineeringIn addition to original research articles, this Research Topic also welcomes reviews, mini-reviews, methods, perspectives, and opinion pieces. Topic editors: Deepa Mundekkad, Blassan George, Dhanjay Jhurry Source: https://www.frontiersin.org/research-topics/78236/sustainable-bio-based-nanocomposites---from-green-synthesis-to-ai-assisted-4d-design-for-advanced-biomedical-engineering