T cell-mediated inflammation and lymphoma in skin

T lymphocytes sit at the center of skin immunity, and chronic dysregulation of the cutaneous inflammatory milieu is increasingly recognised as a driver of malignant transformation. Skin-resident T cells are shaped by sustained interactions with keratinocytes, stromal cells, and other immune populations in the cutaneous microenvironment. When these signals are persistently skewed, they can favor the emergence and expansion of pathogenic T cell subsets, including the malignant clones that define cutaneous T cell lymphomas (CTCL) such as mycosis fungoides and Sézary syndrome.In CTCL, the interplay between malignant and benign T cells is central to disease biology. Cytokines and chemokines produced by malignant lymphocytes amplify local inflammation, reshape the tumor microenvironment, suppress effective anti-tumor responses, and support disease progression. Understanding how a chronically inflamed skin environment selects for, sustains, and educates malignant T cells is key to identifying earlier diagnostic markers and new therapeutic targets.The aim of this Research Topic is to gather advances in T cell biology that connect cutaneous inflammation to lymphomagenesis and CTCL progression. We welcome work that clarifies the molecular and cellular mechanisms by which inflammatory signals shape malignant T cell behavior, the contribution of the tumor microenvironment to immune evasion, and the identification of biomarkers and targets that could inform precision approaches for patients with CTCL. This topic accepts manuscripts in, but not limited to, the following themes:• Inflammatory mechanisms in the skin that promote T cell lymphomagenesis• Molecular and functional biology of malignant versus reactive T cells in CTCL• Cytokine and chemokine networks shaping the CTCL tumor microenvironment• Interactions between malignant T cells, stromal cells, and benign immune cells in lesional skin• Mechanisms of immune evasion and exhaustion in CTCL• Clonal evolution, single-cell, and spatial analyses of cutaneous T cell lymphomas• Novel biomarkers for early diagnosis, staging, and prognosis of CTCL• Emerging therapeutic targets and precision medicine approaches in CTCL Topic editors: Patrizia Fuschiotti, Anjali Mishra, Luis F Santamaria-Babí Source: https://www.frontiersin.org/research-topics/80006/t-cell-mediated-inflammation-and-lymphoma-in-skin