Targeting the Host-Virus Interface: From Mechanistic Insights to Therapeutic Strategies in Animal Viral Diseases

Animal viruses impose substantial economic burdens on the global livestock industry and represent persistent threats to animal health. Furthermore, many of these pathogens jeopardize public health security. As obligate intracellular parasites, viruses depend exclusively on host cellular machinery to execute essential biological processes such as transcription and replication. These processes involve intricate virus–host interactions, particularly the complex interplay between viral and host proteins. Through systematic mapping of virus–host interaction networks, researchers can identify critical host factors indispensable for the viral life cycle. This approach not only advances our mechanistic understanding of viral replication but also uncovers novel targets for developing innovative antiviral therapeutics.This research topic aims to advance our understanding of animal viral pathogenesis through the lens of virus-host interactions, thereby providing a theoretical foundation for developing novel antiviral strategies, including candidate vaccines, pharmaceuticals, and therapeutic antibodies.To gather further insights in the field of virus-host interaction research, we welcome submissions focused on, but not limited to:- Molecular mechanisms underpinning virus-host interactions in pathogenesis.- Discovery and validation of host factors critical to viral infection and replication - Innovative antiviral agents and therapeutics for animal viruses.Topic Editor Dr. Li Mao holds two invention patents (ZL201811167484.3; ZL202011516349.2). The other Topic Editors declare no competing interests with regard to the Research Topic subject. Topic editors: Chongyang Wang, Jie Zhu, Li Mao Source: https://www.frontiersin.org/research-topics/76692/targeting-the-host-virus-interface-from-mechanistic-insights-to-therapeutic-strategies-in-animal-viral-diseases