The application of novel biodegradable biomaterials for the regeneration of bone and tendon tissue

The utilization of biodegradable biomaterials as a therapeutic modality for musculoskeletal tissue regeneration has emerged as a promising avenue for research. Bone and tendon injuries are prevalent and often challenging to treat due to their limited intrinsic healing capacity and the mechanical demands placed on these tissues. Conventional grafts and permanent implants have been associated with complications, including inflammation, infection, and inadequate integration. The utilization of novel biodegradable materials, encompassing bioactive materials, polymer composites, and engineered scaffolds, provides dynamic support by virtue of the provision of temporary mechanical stability, accompanied by gradual degradation, thereby creating space for new tissue formation. The delivery of bioactive cues, the modulation of cell behavior, and the promotion of vascularization render them particularly attractive for bone and tendon repair. Continued innovation in material design is expanding the potential for more effective, biologically harmonious regenerative therapies.The primary goal of this Research Topic is to address the persistent clinical challenges associated with effective regeneration of bone and tendon tissues, both of which exhibit limited endogenous healing capacity and require precise mechanical and biological restoration. Current treatment options, such as autografts and allografts, are constrained by donor-site morbidity, immunological risks, and inconsistent long-term outcomes. Novel biodegradable biomaterials offer a compelling alternative, yet key questions remain regarding how to optimize their composition, degradation kinetics, mechanical performance, and biological functionality to support coordinated tissue repair. To achieve this goal, research must focus on designing biomaterials that mimic the hierarchical structure and biomechanical properties of native tissues while delivering instructive biochemical signals. Recent advances—including bioactive glass–polymer hybrids, nanostructured scaffolds, controlled-release systems for growth factors, and mechanically adaptive materials—demonstrate significant potential to enhance cell recruitment, differentiation, and extracellular matrix (ECM) formation. Integration of emerging technologies such as 3D bioprinting, machine learning–guided material design, and immunomodulatory approaches can further refine these biomaterial systems. By advancing these strategies, the field can move toward reliable, patient-tailored solutions for restoring function in bone and tendon injuries. This Research Topic explores the design and evaluation of novel biodegradable biomaterials for regenerating bone and tendon tissues. It covers basic science and translational studies focused on improving structural, mechanical, and biological integration. Key themes include the development of biodegradable ceramics, polymers, and composites; their degradation to healing dynamics; incorporating bioactive cues or cells; and using advanced fabrication methods such as electrospinning and 3D bioprinting. Additional areas include immunomodulatory biomaterials, optimization of scaffold–tissue interfaces, relevant in vitro and in vivo models, and challenges in clinical translation, all aimed at advancing biomaterial-based musculoskeletal repair. To gather further insights, we welcome all articles types (Brief Research Report, Case Report, Data Report, FAIR² Data, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Systematic Review, Technology and Code). Topic editors: Clemens Gögele, Bahareh Azimi, Janin Reifenrath Source: https://www.frontiersin.org/research-topics/76403/the-application-of-novel-biodegradable-biomaterials-for-the-regeneration-of-bone-and-tendon-tissue