The endothelial interface: bridging hemostasis, autoimmunity, and vascular regeneration

Endothelial cells (ECs) are no longer viewed as passive linings of the vasculature; they are dynamic controllers of blood flow, vessel growth, and immune surveillance. At the intersection of the vascular, nervous, and immune systems lies a complex network of signaling pathways that coordinate how tissues heal and how vessels respond to injury. When these pathways are disrupted, the result is a spectrum of disorders characterized by endothelial dysfunction. This dysfunction manifests in two primary ways: the breakdown of hemostasis, leading to significant bleeding and thrombotic events, and the impairment of vascular architecture, which is a hallmark of connective autoimmune diseases. By recognizing the shared molecular and anatomical features between these systems, we can better understand how vascular disorders transition from localized defects to systemic autoimmune pathologies.The goal of this Research Topic is to bridge the gap between hematology, autoimmunity, and regenerative medicine by identifying the common drivers of defective angiogenesis. A central challenge in modern medicine is the undefined nature of vascular remodeling across different patient populations ranging from those with genetic bleeding disorders to those with systemic connective tissue diseases. We aim to explore how the dysregulation of the vascular-immune interface leads to both hemorrhage and defective tissue regeneration.By combining new developments in cell biology and medical technology, this collection aims to identify molecular pathways connected with clinical signs to facilitate the early recognition of patients at high risk for uncontrolled bleeding, vascular instability, and impaired tissue repair. The ultimate objective of this Research Topic is to provide a platform for an interdisciplinary research community to translate fundamental discoveries into novel pharmacological options and diagnostic tools. These advancements are designed to provide predictive insights into bleeding risks, identify endothelial dysfunction in autoimmune diseases, and monitor vascular stability and tissue regeneration.We invite original research, comprehensive reviews, and translational perspectives that investigate the role of endothelial cells in disease and repair. We are particularly interested in manuscripts that address the following themes:- Mechanisms of Vascular Dysfunction: Investigations into how impaired endothelial signaling drives defective angiogenesis in both genetic and acquired disorders.- The Hemostasis-Inflammation Interface: Studies exploring the link between dysregulated neoangiogenesis leading to vascular leakage. - Autoimmunity and the Vasculature: Research on how the dysfunctional vascular endothelium triggers autoimmune connective tissue diseases and the pathogenetic mechanisms of fibrotic tissue deposition versus repair.- Regenerative Medicine & Cell Therapy: Innovative approaches to vascular healing, including the differentiation of stem cells and the restoration of healthy vessel formation.- Translational Biomarkers: The development of novel diagnostic tools to stratify bleeding risks and monitor the progression of vascular-related autoimmune conditions.- Vascular Remodeling: Insights into how inflammation of perivascular tissues influences the health and remodeling of human vessels. Topic editors: Celestina Mazzotta, Stefano Soldano Source: https://www.frontiersin.org/research-topics/79457/the-endothelial-interface-bridging-hemostasis-autoimmunity-and-vascular-regeneration