The promising potential of autologous-derived products in oral wound healing and tissue regeneration

Biological products stimulating wound healing during surgical procedures have grown enormously in recent decades. Human platelet concentrates, and non-transfusional blood derivates have been proposed to deliver an autologous source of biomolecules locally to enhance wound healing and tissue regeneration. Distinct platelet concentrates such as platelet-rich plasma (PRP) and leucocyte platelet-rich fibrin (L-PRF) have been used widely in dental surgical procedures, periodontal treatments, sinus floor elevation, dental implant therapy, and alveolar ridge preservation. However, the need for knowledge of the precise mechanisms of action, the absence of standardized protocols, and the heterogeneity in clinical studies make it difficult to establish evidence-based clinical guidelines for their clinical use. This research topic is dedicated to the meticulous collection of evidence related to biological mechanisms, clinical research on platelet concentrates, and blood-derived knowledge. We welcome both original research and review articles that address: - the impact of autologous tissue derivates, platelet concentrates on biological activities in oral tissue cells - mechanisms underlying the impact of autologous tissue derivates and platelet concentrates in biological activities to enhance wound healing and tissue regeneration. - the effect of autologous tissue derivates and platelet concentrates on promoting soft and hard tissue regeneration in different clinical situations in the dental practice Topic editors: Constanza Eugenia Martinez, Patricio C Smith Source: https://www.frontiersin.org/research-topics/69453/the-promising-potential-of-autologous-derived-products-in-oral-wound-healing-and-tissue-regeneration