The Role of Glia in Ataxia and Other Neurodegenerative Disorders, Volume II

The progressive loss of function and structure of neuronal cells is a process that falls under the name "neurodegeneration." Regardless of their etiology, neurodegenerative disorders are caused by neuronal loss, which is influenced by glial activation. The role of glial cells in neuronal death has long been debated but has recently been recognized as crucial. However, deciphering the exact contribution of glial cells to neurodegenerative diseases is extremely complex, as they are known to have a dual effect of being helpful and/or harmful. Several types of glial cells, oligodendrocytes, microglia, and astrocytes, have long been considered structural and trophic supports that sustain and protect neurons. However, the initial beneficial response of glial cells can become deleterious at later stages of the disease. The sustained release of reactive oxygen species and pro-inflammatory cytokines leads to neuronal death. In addition, some glial-derived proteases contribute to disease initiation and progression, while others reduce its severity. Furthermore, glial cells adopt different phenotypes and activate specific downstream pathways depending on the type and stage of the disease. Therefore, when developing glia-based therapeutic targets, it is crucial to consider the specific disease and the correct time window for intervention.This topic aims to gather information on glial cells, physiology, and pathology, as an overreaching therapeutic target for neurodegenerative disorders. We hope to learn from different neurodegenerative disorders a clear pathway of helpful and harmful activation of glial cells and overcome the challenges in developing novel therapeutic insights.This Research Topic is a call to explore the role of glial cells physiology and pathology as a potential therapeutic target in neurodegenerative disorders. We welcome original and review papers covering the role of glia in pathologies, such as the following:• Ataxia• Huntington's disease• Parkinson's disease• Motor neuron disease• Multiple system atrophy• Progressive supranuclear palsy• Alzheimer's disease and other memory disorders Topic editors: Rosella Abeti, Milica Cerovic Source: https://www.frontiersin.org/research-topics/78677/the-role-of-glia-in-ataxia-and-other-neurodegenerative-disorders-volume-ii