The Role of Memory Cells in Persistence of Adoptive Cell Therapy

Adoptive cell therapy is a treatment that utilizes immune cells from patients or healthy donors typically engineered with disease targeting antigens to remove the disease-causing cells in patients. One of the main areas of research is how to prolong the persistence of the cells in patients to keep the relapse of the disease-causing cells. The most advanced adoptive cell therapy is the use of CAR T cells, T cells engineered with Chimeric Antigen Receptors that target antigens from cancer cells. To increase persistence of CAR T cells in the body, it has become popular to find methods to increase the culture of memory CAR T cells, cells that maintain active population to keep killing recurring cancer cells. Like CAR T cells, the importance of memory cells has been shown in other adoptive cell therapy involving other types of immune cells.Although there is accumulating literature on the importance of memory cells in adoptive cell therapy, there is no collection of reviews on this emerging topic. Like CAR T cells, finding ways to increase the population of memory cells for other immune cell types involved in adoptive therapy is an active area of research. The goal of this Research Topic is to bring experts in different areas of adoptive cell therapy fields to argue and present the importance of having memory cells in the treatment. The long-term goal is that the Research Topic would further promote research efforts to increase memory potential of cells in adoptive cell therapy.We encourage paper submissions that contain, but need not be limited to, one or more of the following themes:• Biology of memory T cells, NK cells and other immune cells in adoptive cell therapy• Manufacturing techniques to enhance the potential of memory cells in adoptive cell therapy• Molecular markers of memory cell population in adoptive cell therapy• Clinical observation of memory cell population in persistence of adoptive cell therapyPlease note that manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this Research Topic. Topic editors: Raymond Wu, Zhenyu Jia Source: https://www.frontiersin.org/research-topics/72715/the-role-of-memory-cells-in-persistence-of-adoptive-cell-therapy