The role of platelets in shaping immune tolerance and homeostasis

The field of immunological tolerance increasingly highlights the multifaceted roles played by platelets far beyond their classical functions in hemostasis. Recent studies have demonstrated that platelets are not merely passive bystanders in inflammation but are active participants in immune regulation, particularly in maintaining homeostasis and preventing pathological immune responses. Platelets interact with diverse immune cell populations, influencing inflammatory signaling, modulating T regulatory (Treg) cell activity, and contributing to immune cell anergy. Despite these advances, significant questions remain regarding the precise mechanisms by which platelet-derived mediators control the balance between tolerance and activation, especially in contexts such as neuroinflammation, autoimmunity, and thrombo-inflammatory disorders. Emerging evidence points to a pivotal involvement of platelets in fine-tuning immune checkpoints, engaging adenosinergic pathways, and sustaining tolerogenic microenvironments, but gaps persist in linking these phenomena to tangible clinical outcomes or therapeutic interventions.This Research Topic aims to unravel the molecular and cellular mechanisms through which platelets orchestrate immune tolerance and modulatory pathways. We seek to clarify how platelet interactions influence Treg differentiation, expansion, and suppressive function; delineate the contributions of platelet-derived mediators to immune cell anergy; and assess how these processes create microenvironments conducive to immune quiescence. We also encourage investigations into the dualistic nature of platelets, exploring how, under certain pathological conditions, their regulatory roles may give way to pro-inflammatory or prothrombotic activity, thus subverting tolerance and contributing to disease progression. By elucidating connections between platelet biology and core immunological tolerance pathways, we endeavor to promote a deeper mechanistic understanding that may ultimately inform novel therapeutic approaches for immune-mediated disorders.To gather further insights in the boundaries of platelet–immune interactions and their roles in tolerance, we welcome articles encompassing mechanistic, translational, and interdisciplinary investigations. The scope is limited to studies that clearly connect platelet functions with immunological tolerance or related regulatory mechanisms, focusing on molecular, cellular, and physiological levels. We encourage submissions addressing, but not limited to, the following themes:-Platelet-mediated regulation of Treg cell biology and suppressive function-Platelet-derived factors contributing to immune cell anergy and inhibition-Molecular characterization of immune checkpoints and tolerogenic signaling circuits modulated by platelets-Platelet involvement in neuroinflammation and systemic immune regulation-Pathological bypass of tolerance by platelets in immuno-thrombosis and related disease states-Interplay between platelets and other immune cell subsets in establishing or disrupting immune homeostasisArticle types welcomed include: original research, reviews, mini-reviews, perspectives, and methodological reports that directly contribute to our understanding of platelet-driven immune tolerance. The topic editors declare no conflict of interest Topic editors: Jyotsna Kailashiya, Bhavana Singh, Sanjay Varikuti, Sunil Singh Source: https://www.frontiersin.org/research-topics/78611/the-role-of-platelets-in-shaping-immune-tolerance-and-homeostasis