Therapies Across a Lifespan: Effects on Oral and Systemic Systems

A comprehensive understanding of the interactions between oral and systemic therapies is essential for evaluating their impact on health throughout the human lifespan. As medical and dental treatment strategies advance, research increasingly reveals that interventions may have effects that extend beyond their intended targets. For instance, oral therapies can influence systemic health, while systemic therapies may have consequences for oral health. These bidirectional effects are modulated by numerous factors, including age, genetic background, environmental exposures, and lifestyle choices. As a result, there is considerable variability between individuals and sometimes unpredictable therapeutic outcomes.Significant progress has been made in recognising the link between oral health and systemic disease, especially as populations age. However, many mechanisms underlying these relationships remain to be clarified. This indicates a continued need for research focused on characterising both beneficial and adverse interactions between oral and systemic therapies.This Research Topic aims to advance our understanding of how interventions targeting oral health may produce systemic effects, and how systemic treatments may impact oral health across the lifespan. Particularly important are the ways these therapeutic interactions are influenced by age-related physiological changes, alterations in the microbiome, and the natural aging process. By investigating both intended and unintended therapeutic effects, we hope to contribute to the development of more precise and individualised treatment strategies that consider patient variability and age-related changes. Ultimately, this will support improved health outcomes.We invite submissions that examine the mechanisms by which oral and systemic therapies exert local and systemic effects throughout life and that identify previously unrecognised interactions. Topics may include, but are not limited to:• The role of individual factors, such as genetics, environment, diet, and lifestyle, on the effectiveness of oral versus systemic therapies.• Comparative studies on the effects of therapies used in oral and systemic health, including short- and long-term impacts.• The influence of aging on therapeutic outcomes, including immune, genetic, and microbiota modifications.• Technological tools for assessing biological functions and impacts of therapies over time.Submissions should provide rigorous insights into the short-term and long-term effects on oral versus systemic tissues, including changes in therapeutic responsiveness with aging. Topic editors: Martha J Somerman, Francisco Nociti Source: https://www.frontiersin.org/research-topics/72569/therapies-across-a-lifespan-effects-on-oral-and-systemic-systems