Type I interferon skin signatures across autoimmune, autoinflammatory, and infectious diseases: when friend turns foe

Dysregulated type I interferon (IFN-I) signaling drives tissue pathology across systemic autoimmune, autoinflammatory, and infectious diseases. While essential for antiviral host defense, sustained or excessive IFN-I production fuels chronic inflammation, autoantibody generation, and organ damage. The skin frequently acts as an accessible window into these systemic processes, displaying distinct IFN-I driven signatures that serve as both clinical indicators of disease activity and potential drivers of local tissue destruction.A clearer understanding of the cellular and molecular mechanisms governing IFN-I pathway initiation and activation, particularly within the skin, is critical for identifying novel therapeutic targets and developing tailored, patient-specific interventions. This Research Topic aims to consolidate mechanistic, clinical, and translational insights into IFN-I signaling across dermatology, rheumatology, and infectious disease, exploring how cutaneous signatures can inform better diagnostic and targeted therapeutic strategies.We welcome the submission of Original Research, Review, Mini Review, and Perspective articles covering themes including, but not limited to:- Mechanisms of IFN-I signaling in cutaneous and systemic autoimmune disorders, including systemic lupus erythematosus, systemic sclerosis, dermatomyositis, rheumatoid arthritis, and inflammatory myopathies- IFN-I skin signatures in inflammatory dermatoses such as psoriasis, atopic dermatitis, alopecia areata, cutaneous drug reactions, and cutaneous malignancies- Role of IFN-I pathways in infectious diseases and host defense, with particular interest in leprosy and leprosy reactions- Advances in targeted therapies directed against IFN-I pathways, including JAK inhibitors, anti-IFN antibodies, and receptor antagonists- Emerging biomarkers and translational models evaluating IFN-I expression profiles in tissue and circulation Topic editors: Abheek Sil, Sara Sebnem Kilic Source: https://www.frontiersin.org/research-topics/81742/type-i-interferon-skin-signatures-across-autoimmune-autoinflammatory-and-infectious-diseases-when-friend-turns-foe