Unveiling the interplay between epigenetics, metabolism, and cancer immunity

The field of cancer research is increasingly exploring the intricate intersections among epigenetics, cancer metabolism, and immunotherapy. These intersecting domains offer immense potential for advancing cancer treatment and patient outcomes. Epigenetic modifications, which regulate gene expression without altering the DNA sequence itself, are capable of rewiring cancer metabolism and have shown significant promise in influencing the tumor microenvironment and enhancing immune responses. Metabolic reprogramming in cancer cells is crucial for their growth and survival, while various metabolites can also affect how immune cells recognize and attack tumors, evoking the concept of immunometabolism in the context of immunotherapy. Understanding the dynamic crosstalk between these biological processes is fundamental to developing innovative and more effective therapeutic strategies.This Research Topic seeks to unravel the complex relationships among these three areas. Specifically, it aims to answer critical questions such as how epigenetic therapies can increase the effectiveness of immunotherapies, how changes in cancer metabolism impact immune function, and how these two processes influence one another reciprocally. By examining these interactions, the Research Topic aims to uncover novel approaches to overcoming therapy resistance and improving cancer treatment efficacy.This Research Topic encompasses a diverse range of studies and themes. While broad in scope, it focuses on the interconnections between these fields:• Epigenetics' role in enhancing cancer immunotherapy• Identification of metabolic pathways' influence on immune cell function• Investigating the interactions between cancer metabolism and immune responses• Reciprocal regulation between epigenetic changes and metabolic reprogramming across cancer cell types• Development of combined therapeutic strategies employing insights from these intersectionsWe invite original research articles, reviews, and perspectives that contribute to these themes and expand our understanding of the crosstalk between epigenetics, cancer metabolism, and immunotherapy. By contributing to this comprehensive overview, researchers can pave the way for more integrated and targeted cancer therapies. Topic editors: Peng Xu, Alessandro Loglio Source: https://www.frontiersin.org/research-topics/73089/unveiling-the-interplay-between-epigenetics-metabolism-and-cancer-immunity