Vaccines for Viral Pathogens in People Living with HIV: From Immune Responses to Clinical Outcomes

People living with HIV represent a unique population in the field of infectious disease and immunology due to persistent immune dysregulation and an increased risk for a variety of viral pathogens. Despite significant advancements in antiretroviral therapy, people living with HIV remain more susceptible to severe outcomes from viral infections, and their responses to vaccines can differ substantially from the general population. While current research has provided insights into the mechanisms of immune impairment and the challenges in generating robust vaccine-mediated protection, there remain considerable gaps. For instance, the variability in vaccine-induced humoral and cellular responses and the persistence of protection over time are still subject to ongoing investigation. Recent studies have begun to elucidate the influence of immune status, co-infections, comorbidities, and vaccine type on effectiveness, but translating immunological findings into clinical outcomes is an evolving area demanding further attention.This Research Topic aims to advance understanding of how people living with HIV respond to vaccines targeting viral pathogens, bridging immunological mechanisms with clinical endpoints. It seeks to identify determinants of vaccine efficacy and safety in this vulnerable population, clarify the interplay between immune dysregulation and protective immunity, and offer translational insights to inform tailored vaccination strategies. By fostering the integration of basic, translational, and clinical studies, this collection aspires to improve prevention and management of viral infections in people living with HIV and inform global health policy.The scope of this Research Topic encompasses studies focused specifically on the development, evaluation, and implementation of vaccines against viral pathogens in the context of HIV infection, with a translational lens toward clinical outcomes. Articles must include an aspect of vaccine research and relevance to human health in people living with HIV populations. We welcome submissions addressing, but not limited to, the following themes:- Immunogenicity and durability of vaccine responses in people living with HIV- Identification and use of adjuvants to enhance vaccine efficacy- Impact of immune status, viral suppression, and comorbidities on vaccine effectiveness- Novel or universal vaccines for viral pathogens in HIV- Vaccine safety and tolerability in immunocompromised populationsTranslational models linking preclinical or immunological findings to patient outcomes- Real-world strategies for improving vaccine uptake and coverage in people living with HIV- Clinical trial data, observational studies, and translational research relevant to vaccine responses Topic editors: Konstantinos Protopapas, Justyna Kowalska Source: https://www.frontiersin.org/research-topics/79018/vaccines-for-viral-pathogens-in-people-living-with-hiv-from-immune-responses-to-clinical-outcomes