Venom toxins as immunomodulators and their therapeutic potential

Animal venoms are a prolific source of bioactive compounds that exhibit distinct pharmacological properties. Recent studies have highlighted the potential of specific venom-derived components to modulate immune pathways and influence cellular responses pertinent to autoimmune diseases, metabolic disorders and cancer. This emerging understanding underscores the therapeutic potential of venom-derived toxins in the context of immune modulation and disease management. The in-depth characterization of venom-derived molecules that affect the immune system not only helps in understanding the venom pharmacology, but also provides a deeper understanding on the immunomodulatory potential of these constituents.This Research Topic aims to bring together cutting-edge original research, comprehensive reviews, and translational perspectives on the potential of venom toxins as immunomodulators, particularly regarding their roles in autoimmune diseases, metabolic disorders and cancer.• To compile and analyze recent findings on venom-derived compounds that exhibit immunomodulatory activity, emphasizing their potential for therapeutic intervention in autoimmune diseases, metabolic disorders and cancer• To explore the molecular mechanisms through which venom toxins affect immune cell function.• To discuss translational advancements and the potential challenges of developing venom-based immunotherapies for clinical applications.• To identify research gaps and propose future directions in the study of venom toxins, aiming to foster innovative strategies for drug discovery and development.• Proteomics and metabolomics studies on animal venom and identification of proteins/metabolites with immunomodulatory potential• Purification and characterization of venom-derived molecules having immunomodulatory potential Topic editors: Muralidharan Vanuopadath, Somanathapura Kumarswamy NaveeKumar, Sakthivel Vaiyapuri, Bhargab Kalita Source: https://www.frontiersin.org/research-topics/72391/venom-toxins-as-immunomodulators-and-their-therapeutic-potential