Correction: How to develop a sustainable palladium-catalyzed cross-coupling reactions for active ingredient manufacture

There was a mistake in Table 1 as published. A table cell contains 2 separate equations, but their present juxtaposition in the published version means it is not clear that they are in fact separate. The corrected Table 1 appears below, where the existence of two separate equations has been made more clear. The equations themselves have been additionally modified slightly to clarify their meaning.

TABLE 1. Metrics relevant to the development of a high turnover palladium-catalyzed cross-coupling.

When quoted alongside the temperature, solvent and concentration, a useful proxy for catalyst productivity is: moles of substrate converted to product moles of catalyst used time

The calculation of TOF, or TON, is most meaningful for the initial rate region before catalyst degradation can make an impact, and when product formation is pseudo-linear with time (Kozuch and Martin, 2012). Rather than being considered solely in isolation, they are better applied as part of the evaluation of very similar conditions side by side, as with the effect of changing the ligand. There are standard conditions (1 M for limiting reactant, 0 °C) whose use simplifies reporting requirements.

T O F t = 1 C a t t · d P r o d d t ,

T O F 0 = 1 C a t 0 · d P r o d d t 0

The original article has been updated.

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Footnotes

Approved by: Pablo Domínguez de María, Sustainable Momentum, SL, Spain