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Frontiers in Neuroanatomy ·

Volume 20 - 2026 | https://doi.org/10.3389/fnana.2026.1824372

Correction: Unveiling the mechanisms of neuropathic pain suppression: perineural resiniferatoxin targets Trpv1 and beyond

  • Safa Shehab1*corresponding author
  • Hayate Javed1
  • Aishwarya Mary Johnson1
  • Saeed Tariq1
  • Challagandla Anil Kumar1
  • Bright Starling Emerald1
  1. Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates
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Abstract

Keywords

In the published article, incorrect images were erroneously included in Figure 5B, 5E. The corrected Figure 5 appears below.

Double immunofluorescent labeling of either Piezo2 **(A–C)** and Trpv1 **(D–F)** or Kv1.1 **(G–I)** and Trpv1 **(J–L)** neurons in control right L4 DRG (R4 cont, **A, D, G, J**) and left L4 DRGs following 14 days of the perineural application of vehicle **(B, E, H, K)** or 0.002% RTX **(C, F, I, L)** on the left L4 nerve. Piezo2+ **(A–C)** and Kv1.1+ **(G–I)** immunoreactivities were mainly localized in large-sized neurons, while Trpv1+ neurons were mainly found in small-sized neurons **(D–F, J–L)** with negligible colocalization. RTX treatment showed a significant reduction in the number of Trpv1+ neurons (<sup>***</sup>*p* < 0.001) **(F, L)** but produced no effect on the Piezo2+ **(C)** or Kv1.1+ neurons **(L)** (*p* > 0.05) **(I)** in the L4 DRG compared to the right control and vehicle-treated L4 DRGs **(A, B, G, H)**. *n* = 3–4, scale bar = 50 μm.
Figure 1. Double immunofluorescent labeling of either Piezo2 (A–C) and Trpv1 (D–F) or Kv1.1 (G–I) and Trpv1 (J–L) neurons in control right L4 DRG (R4 cont, A, D, G, J) and left L4 DRGs following 14 days of the perineural application of vehicle (B, E, H, K) or 0.002% RTX (C, F, I, L) on the left L4 nerve. Piezo2+ (A–C) and Kv1.1+ (G–I) immunoreactivities were mainly localized in large-sized neurons, while Trpv1+ neurons were mainly found in small-sized neurons (D–F, J–L) with negligible colocalization. RTX treatment showed a significant reduction in the number of Trpv1+ neurons (***p < 0.001) (F, L) but produced no effect on the Piezo2+ (C) or Kv1.1+ neurons (L) (p > 0.05) (I) in the L4 DRG compared to the right control and vehicle-treated L4 DRGs (A, B, G, H). n = 3–4, scale bar = 50 μm.

The original version of this article has been updated.

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Footnotes

Edited and reviewed by: Stefania Raimondo, University of Turin, Italy

Citation

Shehab, S., et al. (2026). Correction: Unveiling the mechanisms of neuropathic pain suppression: perineural resiniferatoxin targets Trpv1 and beyond. Frontiers in Neuroanatomy, Volume 20. https://doi.org/
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20 - 2026

Copyright

Copyright © 2026 Shehab, Javed, Johnson, Tariq, Kumar and Emerald.

License: https://creativecommons.org/licenses/by/4.0/

*Correspondence: Safa Shehab

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