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Frontiers in Neuroenergetics ·

Volume 2 - 2010 | https://doi.org/10.3389/fnene.2010.00018

Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms

  • Fahmeed Hyder1,2,3,4*corresponding author
  • Basavaraju G. Sanganahalli1,2,3
  • Peter Herman1,2,3
  • Daniel Coman1,2,3
  • Natasja J. G. Maandag1,3
  • Kevin L. Behar1,2,5
  • Hal Blumenfeld6,7,8
  • Douglas L. Rothman1,2,3,4
  1. 11 Magnetic Resonance Research Center, School of Medicine, Yale University New Haven, CT, USA
  2. 22 Core Center for Quantitative Neuroscience with Magnetic Resonance, School of Medicine, Yale University New Haven, CT, USA
  3. 33 Department of Diagnostic Radiology, School of Medicine, Yale University New Haven, CT, USA
  4. 44 Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University New Haven, CT, USA
  5. 55 Department of Psychiatry, School of Medicine, Yale University New Haven, CT, USA
  6. 66 Department of Neurology, School of Medicine, Yale University New Haven, CT, USA
  7. 77 Department of Neurosurgery, School of Medicine, Yale University New Haven, CT, USA
  8. 88 Department of Neurobiology, School of Medicine, Yale University New Haven, CT, USA
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Abstract

Functional magnetic resonance imaging (fMRI) with blood-oxygenation level dependent (BOLD) contrast is an important tool for mapping brain activity. Interest in quantitative fMRI has renewed awareness in importance of oxidative neuroenergetics, as reflected by cerebral metabolic rate of oxygen consumption ( CMR O 2 ) , for supporting brain function. Relationships between BOLD signal and the underlying neurophysiological parameters have been elucidated to allow determination of dynamic changes in CMR O 2 by “calibrated fMRI,” which require multi-modal measurements of BOLD signal along with cerebral blood flow (CBF) and volume (CBV). But how do CMR O 2 changes, steady-state or transient, derived from calibrated fMRI compare with neural activity recordings of local field potential (LFP) and/or multi-unit activity (MUA)? Here we discuss recent findings primarily from animal studies which allow high magnetic fields studies for superior BOLD sensitivity as well as multi-modal CBV and CBF measurements in conjunction with LFP and MUA recordings from activated sites. A key observation is that while relationships between neural activity and sensory stimulus features range from linear to non-linear, associations between hyperemic components (BOLD, CBF, CBV) and neural activity (LFP, MUA) are almost always linear. More importantly, the results demonstrate good agreement between the changes in CMR O 2 and independent measures of LFP or MUA. The tight neurovascular and neurometabolic couplings, observed from steady-state conditions to events separated by <200 ms, suggest rapid oxygen equilibration between blood and tissue pools and thus calibrated fMRI at high magnetic fields can provide high spatiotemporal mapping of CMR O 2 changes.

Keywords

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Citation

Hyder, F., et al. (2010). Neurovascular and Neurometabolic Couplings in Dynamic Calibrated fMRI: Transient Oxidative Neuroenergetics for Block-Design and Event-Related Paradigms. Frontiers in Neuroenergetics, Volume 2. https://doi.org/
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Copyright © 2010 Hyder, Sanganahalli, Herman, Coman, Maandag, Behar, Blumenfeld and Rothman.

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*Correspondence: Fahmeed Hyder

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