Lactate Fuels the Neonatal Brain

Abstract

References

1. Boumezbeur F., Petersen K. F., Cline G. W., Mason G. F., Behar K. L., Shulman G. I., Rothman D. L. (2010). The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J. Neurosci. 30, 13983 – 13991. doi:10.1523/JNEUROSCI.2040-10.2010
2. Brennan A. M., Connor J. A., Shuttleworth C. W. (2006). NAD(P)H fluorescence transients after synaptic activity in brain slices: predominant role of mitochondrial function. J. Cereb. Blood Flow Metab. 26, 1389 – 1406. doi:10.1038/sj.jcbfm.9600292
3. Caesar K., Hashemi P., Douhou A., Bonvento G., Boutelle M. G., Walls A. B., Lauritzen M. (2008). Glutamate receptor-dependent increments in lactate, glucose and oxygen metabolism evoked in rat cerebellum in vivo. J. Physiol. 586, 1337 – 1349. doi:10.1113/jphysiol.2007.144154
4. Duchen M. R. (1992). Ca2 + -dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochem. J. 283, 41 – 50.
5. Erecinska M., Cherian S., Silver I. A. (2004). Energy metabolism in mammalian brain during development. Prog. Neurobiol. 73, 397 – 445.
6. Foster K. A., Beaver C. J., Turner D. A. (2005). Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. Neuroscience 132, 645 – 657. doi:10.1016/j.neuroscience.2005.01.040
7. Galeffi F., Foster K. A., Sadgrove M. P., Beaver C. J., Turner D. A. (2007). Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. J. Neurochem. 103, 2449 – 2461. doi:10.1111/j.1471-4159.2007.04939.x
8. Ivanov A., Mukhtarov M., Bregestovski P., Zilberter Y. (2011). Lactate effectively covers energy demands during neuronal network activity in neonatal hippocampal slices. Front. Neuroenerg. 3: 2. doi:10.3389/fnene.2011.00002
9. Kann O., Schuchmann S., Buchheim K., Heinemann U. (2003). Coupling of neuronal activity and mitochondrial metabolism as revealed by NAD(P)H fluorescence signals in organotypic hippocampal slice cultures of the rat. Neuroscience 119, 87 – 100. doi:10.1016/S0306-4522(03)00026-5
10. Kasischke K. A., Vishwasrao H. D., Fisher P. J., Zipfel W. R., Webb W. W. (2004). Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis. Science 305, 99 – 103. doi:10.1126/science.1096485
11. Lipton P. (1973). Effects of membrane depolarization on nicotinamide nucleotide fluorescence in brain slices. Biochem. J. 136, 999 – 1009.
12. Misgeld T., Kerschensteiner M., Bareyre F. M., Burgess R. W., Lichtman J. W. (2007). Imaging axonal transport of mitochondria in vivo. Nat. Methods 4, 559 – 561.
13. Mofett D. F., LaManna J. C. (1978). Contributions of glycolysis and oxidative metabolism to recovery from electrical pulses in toad brain. Brain Res. 152, 365 – 368. doi:10.1016/0006-8993(78)90265-2
14. Nimmerjahn A., Kirchhoff F., Kerr J. N., Helmchen F. (2004). Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo. Nat. Methods 1, 31 – 37.
15. Pellerin L., Magistretti P. J. (1994). Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. U.S.A. 91, 10625 – 10629.
16. Schurr A., West C. A., Rigor B. M. (1988). Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240, 1326 – 1328. doi:10.1126/science.3375817
17. Shuttleworth C. W. (2010). Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation. Neurochem. Int. 56, 379 – 386.
18. Shuttleworth C. W., Brennan A. M., Connor J. A. (2003). NAD(P)H fluorescence imaging of postsynaptic neuronal activation on murin hippocampal slices. J. Neurosci. 23, 3196 – 3208.