Review
Published
Application of large language models in early screening of Alzheimer’s disease: a scoping review
Jianan Tian · Weidong Huang · Yongmei Wen · Yifan Liang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1906641
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 50 articles
Case Report
Published
Case Report: Longitudinal evaluation of cerebrospinal fluid Alzheimer’s disease core biomarkers in a case of refractory late-onset epilepsy of unknown etiology
Takafumi Wada · Akira Kuzuya · Kazuma Koda · Sakiho Ueda · Atsushi Shima · Nobukatsu Sawamoto · Akio Ikeda · Ryosuke Takahashi · Riki Matsumoto
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1807027
Original Research
Published
A clustering approach based on neuropsychological testing to detect early signs of probable MCI among community-dwelling older adults
Rafael Mauti · Chiraz Chouk · Aymeric Guillot · Arnaud Peronin · Patrick Fargier · Pascal Chabaud
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1926431
Review
Published
Digital biomarkers derived from wearable and portable devices in prodromal Parkinson’s disease and at-risk populations: a scoping review
Ting Yu · Qian Wang · Mingxia Pan · Yuanfang Xiong · Shiya Hu · Yiping Deng · Lingyu Kuang · Hanjiao Liu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1850991
Review
Published
Tavapadon in Parkinson’s disease: D1/D5 receptor pharmacology, clinical evidence, and translational perspectives
Mohamed Alsharif · Omran Shrebaty · Mohammad Oudah · Raghad Saud AlOubili · Dalal Mohammed Akram Motabagani · Jenan M. Alnamly · Gadi Khalid Sindi · Ahmad E. L. Bana
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1959744
Original Research
Published
Camk2d upregulation is associated with postoperative cognitive dysfunction in aged rats: pharmacological inhibition of CaMKII attenuates hippocampal neuroinflammation and neuronal apoptosis
Kaihua Wei · Shiwen Fan · Yujia Zhao · Xiaobin Cai · Xinlei Qin · Jingwen Zhai · Liping Xie
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1975677
Original Research
Published
Beyond retest gains: episodic memory practice effects and longitudinal cognitive trajectories in cognitively healthy adults
Simon Fankhauser · Gabriele Cattaneo · Gemma Albi-Villuendas · Javier Solana-Sánchez · Álvaro Pascual-Leone · David Bartrés-Faz
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1933991
Original Research
Published
Inflammatory and cardiac-stress biomarkers in Moyamoya disease: the role of GDF-15
Fengxia Guo · Hanxiao Li · Qiushi Guo · Yumeng Wang · Xiaohuan Zhang · Weiguang Luo
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1906016
Editorial
Published
Editorial: Imaging biomarkers in neurodegenerative diseases: advances and challenges
Francesco Lanfranchi · Andrew R. Bender · Lucas Caldi Gomes
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.2009935
Hypothesis and Theory
Published
A SynNotch-PiggyBac gene circuit for inflammation-responsive IL-10 delivery in Alzheimer’s disease: a hypothesis and design framework
Suhani Gupta · Ronav Gupta
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1866161
Mini Review
Published
Molecular mechanisms underpinning cognitive reserve and resilience
Amber Chen · Sreenithi Bhuvaneshwaran · Yash Akkara · Thomas Burke · Robert Perneczky · Magdalena Sastre
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1957901
Original Research
Published
TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathology
Zheng Liu · Yuchen Yu · Yu Wang · Shuohan Ning · Tongshuai Huang · Jingqi Li · Sihan Fan · Chaolong Lu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1920487
Review
Published
Neuromodulatory interventions for Alzheimer’s disease
Ruofan Wang · Botao Zhu · Qingda Guo · Jun Steed Huang · Wandong Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1925914
Review
Published
Iron-related biomarkers and Lewy body dementia: a scoping review
Jessica L. Freeling · Lisa M. McFadden
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1900516
Original Research
Published
Immediate anxiety-reducing effects of multisensory virtual reality reminiscence therapy in older adults with a wide range of cognitive functions: a pilot study using electrophysiological measures
Keita Ueno · Kazuyuki Niki · Hiroyuki Tanaka · Takeshi Okuda · Daisuke Iwai · Kosuke Sato · Yasuo Naito · Toshinori Ito · Ryouhei Ishii
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1958403
Review
Published
GLP-1 receptor agonists as potential disease-modifying agents in Parkinson’s and Alzheimer’s disease: mechanisms, clinical trial evidence, and the neuroprotection horizon
Mohamed Alsharif · Omran Shrebaty · Mohammad Ammar Aloudah · Mayar Alqahtani · Raghad Saud Aloubili · Marafi Jammaa Ahmed · Bana Albani · Ahmad El Bana
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1969490
Systematic Review
Published
Gait characteristics in people with central nervous system disorders under dual-task experimental paradigms: a scoping review
Haizhe Jin · Jiahao Zhang · Xinyi Meng · Jianing Li · Su Meng · Quanwei Fu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1807030
Review
Published
Pyroptosis: a potential target and research progress of exercise in ameliorating Alzheimer’s disease pathology
Shao Jie · Zhu Lei
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1983962
Original Research
Published
Voxelwise degree centrality alterations and cognitive performance in severe unilateral M1-segment middle cerebral artery stenosis with ipsilateral watershed infarction
Zhilin Huang · Xiaoxue Liang · Liyong Li · Yude Wei · Yi Zhang · Wenqian Wei · Xuanmei Quan · Kanglei Li · Kunlong Yao · Jian Tang · Yueling Zhang · Jianyi Huang · Jian Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1969092
Original Research
Published
Reduced serum LEFTY2 and disease-dependent biomarker associations in Alzheimer’s disease: an exploratory study
Wei Wuli · Raymond Y. Lo · Horng-Jyh Harn · Tzyy-Wen Chiou · Yue-Xuan Xu · Yuncin Luo · Ivan Wijaya · Shinn-Zong Lin
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1955495
Original Research
Published
Association of statin use with reduced risk of Alzheimer’s disease: findings in UK Biobank
Hui Yang · Can Zhu · Jialu He · Yan Wei · Dongmei Li · Xuan Luo · Ying Wang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1961033
Original Research
Published
Is easy-to-read easy for everyone? An eye-tracking study across the adult lifespan
Sergio Navas-León · Jon Andoni Duñabeitia
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1916339
Original Research
Published
Transcriptomic analysis identifies candidate molecular mechanisms underlying SCF+G-CSF-reduced neuropathology in aged APP/PS1 mice
Afua Addo · Bin Li · Sasidhar Murikinati · Robert Gardner · Li-Ru Zhao
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1705436
Original Research
Published
Dual-scale assessment of motor dysfunction in older adults with locomotor dysfunction and its association with gait and muscle activation
Wen Liu · Chunxiao Lu · Lifeng Qian
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1980454
Review
Published
Epigenetics in Alzheimer’s disease: from molecular mechanisms to emerging novel biomarkers
Elisabetta D’Aversa · Miriana Grisafi · Salvatore Pernagallo · Francesca Salvatori · Ajay V. Singh · Alessia Nucciarone · Veronica Tisato · Donato Gemmati
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1959361
Original Research
Published
Atherosclerotic cardiovascular disease risk is associated with AT(N)V neuroimaging biomarkers and cognitive impairment in the health and aging brain study–health disparities cohort
Kimberly Espejo · Ryan Rulkens · Cellas A. Hayes · Joey A. Contreras
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1874472
Review
Published
Dexmedetomidine as a potential neuroprotective agent against Alzheimer’s disease: molecular mechanisms and therapeutic perspectives
Jun Kang · Yongbo Duan · Jiaxuan Bi · Jiangping Liu · Wenjun Yan
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1952923
Systematic Review
Published
Comparative efficacy of non-pharmacological interventions for amnestic mild cognitive impairment: a network meta-analysis
Baofang Zhang · Xuanling Li · Qian Zhao · Shuqun Zhang · Yuquan Bai · Youlin Duan · Caien Yu · Chenlin Sui · Aochen Yang · Lianwei Xu
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1878590
Original Research
Published
Digital mobility assessment using wearable devices in people with Parkinson’s disease: a feasibility and implementation study in Ghana (TraPCAf) compared with a UK cohort
Metin Bicer · Cameron Kirk · Mary Agoriwo · Momodou Cham · Albert Akpalu · Njideka Okubadejo · Javad Sarvestan · Jack Lumsdon · Yasin Okkaoglu · Katie Brittain · Ríona McArdle · Lisa Alcock · Alison J. Yarnall · Natasha Fothergill-Misbah · Richard Walker · Lynn Rochester · Silvia Del Din · TraPCAf
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1899045
Original Research
Published
Associations between inflammatory-lipid indices and clinical outcomes in ischemic stroke patients treated with mechanical thrombectomy
Ao Qian · Jia Duan · Wenli Xing · Longyi Zheng · Shuang Tang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1919645
Original Research
Published
Rasch-based classification of post-stroke balance ability: dimensionality and clinical validation of the BESTest and S-BESTest
Thitimard Winairuk · Marco Y. C. Pang · Sirod Sirisup · Vitoon Saengsirisuwan · Kamolwan K. Klaykaew · Rumpa Boonsinsukh
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1889177
Perspective
Published
Hydrogen gas and olfactory dysfunction in Alzheimer’s disease: the Hydrogen–Olfactory–Limbic hypothesis
Ligao Bao · Dunfu Eer
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1937419
Original Research
Published
Longitudinal changes in hand dominance and manual dexterity in normal aging and mild cognitive impairment (MCI): a kinematic study
Olena Vasylenko · Claudia Rodríguez-Aranda
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1921208
Original Research
Published
Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch
Carlye Frisch · Lauren Baker · Gayathri Srinivasan · Albert E. Mintah · Salma Leyasi · Morgan Pedroza · Brooke Galyon · David A. Brafman
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1856154
Original Research
Published
Eye-movement-based machine learning for identifying Parkinson’s disease dementia in a retrospective cohort: an interpretable model-development study
Jing Wu · Qing Liu · Song Yang · Yuqing Zhang · Yuanlu Shu · Junwen Wang · Min Wu · Tian Tian
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1935091
Original Research
Published
Auditory performance and cortical plasticity in blind individuals with sensorineural hearing loss: insights into dual sensory impairment
Min Young Kwak · Jeong-Sug Kyong · Hyo Jung Choi · Yong-Hwi An · Hyun Joon Shim
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1769582
Original Research
Published
No evidence that serum metabolite slopes improve held-out prediction of clinical progression in the Alzheimer’s disease neuroimaging initiative
Tia Warrick · Manali Misra · Stephen Kataria · Jahnavi Patel · Bhuvi Ajmera
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1942662
Systematic Review
Published
Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysis
Haotian Wu · Yujie Wang · Zhifeng Gao · Huan Zhang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1899745
Brief Research Report
Published
Cardiorespiratory fitness is associated with cerebral oxygen extraction in Alzheimer’s disease
Paul J. Kueck · Zachary D. Green · Raechel Camones · Casey S. John · Robyn A. Honea · Jeffrey M. Burns · Eric D. Vidoni · Jill K. Morris
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1943472
Original Research
Published
Carotid atherosclerosis progression in patients with Parkinson’s disease: a prospective cohort study
Siyu Wang · Ni Yang · Haoyang Cheng · Qingbo Zhou
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1928073
Original Research
Published
Behavioral markers of motor reserve: stability, lateralization, and consistency
David Vagni · Emanuela Principe · Melissa Pirrotta · Laura Catalano · Chiara Milasi · Morena De Francesco · Andreina Giustiniani · Chiara Arena · Francesco Scarfone · Angelo Quartarone · Domenico Bosco · Giovanni Pioggia · Antonio Cerasa
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1921302
Original Research
Published
Complement C4b and factor B in astrocyte-derived exosomes as novel biomarkers for amnestic mild cognitive impairment
Yu Li · Menglu Zhang · Chao Ying · Chao Han · Qimeng Li · Yanning Cai
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1727449
Original Research
Published
Self-reported chewing or swallowing problems and episodic memory performance in older Americans: a longitudinal cohort study
Fei He · Chonghao Yao · Xuteng Kang · Yihao Ding · Haoqi Tu · Sijia Na
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1899130
Original Research
Published
Prediction of cognitive impairment in Parkinson’s disease using TabPFN: an integrative analysis of clinical data, longitudinal trajectories, and lipidomics
Zikai Zhou · Jie Liu · Lijuan Wang · Hong Lv · Wencan Jiang · Ling Huang · Guojun Zhang · Ruimin Ma
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1905374
Original Research
Published
Resting-state cortical alpha frequency in Parkinson’s disease and multiple system atrophy: associations with diagnosis, age, and symptom burden
Daichao Chen · Huada Tang · Yanfei Pan · Hui Sang · Saiya Gu · Xinpeng Wang · Kai Li · Fan Li · Yunchuang Sun · Jing Chen · Wei Sun · Jue Zhang · Zhaoxia Wang · Luhua Wei
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1928414
Original Research
Published
Electroacupuncture inhibits pyroptosis to improve motor function in an MPTP-induced mouse model of Parkinson’s disease
Yu-Chen Ying · Yi-Yue Dong · Guang-Yan Chen · Xi Wang · Qian Fan · Xi-Chen Wu · Yue-Lai Chen
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1968826
Original Research
Published
Multicomponent training versus elastic-band training for improving global cognition and executive function in older women: a randomized controlled trial
Edgar Vásquez-Carrasco · Pablo Aravena-Sagardia · Mauricio Barramuño-Medina · Sebastián Valenzuela-Rosel · Victor Alarcón-Zambrano · Jordan Hernandez-Martinez · Roberto López-Andaur · Cristian Sandoval-Vásquez · Braulio Henrique Magnani Branco · Pablo Valdés-Badilla
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1911384
Original Research
Published
Selective autophagy inhibition alleviates oxidative stress-associated neurodegeneration in an AD+CCH model
Xiaorui Huang · Jufang Chen · Zhicheng Lu · Jie Wang · Xuelian Luo · Qiuyan Qin · Qin Yang · Chongdong Jian · Xuebin Li · Jingwei Shang
Frontiers in Aging Neuroscience
doi 10.3389/fnagi.2026.1870441