Perspective
Published
Bridging communication gaps across the biomedical ecosystem
Elizabeth A. Burke · Samantha N. Schumm · Amy Jobe · Kara Whelply · Ishita Das
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1939110
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 50 articles
Original Research
Published
Phylogenetic tree inference with tropical axial attention
Chris Teska · Kurt Pasque · Ruriko Yoshida · Baran Hashemi
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1886918
Original Research
Published
Addressing biomedical complexity using the energy systems language
Federico Surra · Francesco Gonella · Luigi Conte · Alessandra Romano
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1903662
Perspective
Published
On matrix-analytic Markov modulated models for evolution: application potential and future directions required to advance the field
Małgorzata M. O’Reilly · Barbara R. Holland
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1906462
Hypothesis and Theory
Published
Coherence, transformation, and breakdown in living systems: part I — the common higher-order regulatory architecture (CHORA) hypothesis
Andreas Nicolaides
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1910966
Review
Published
Explainable artificial intelligence (XAI) in schizophrenia: enhancing transparency in clinical decision-making
Kshitij Srivastava · Ruby Srivastava
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1898853
Perspective
Published
The archibiome: extending engineered living materials to multiscale built environments
A. Sandak · W. Pajerski · A. Gubenšek · K. Butina Ogorelec · A. Černoša
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1943876
Review
Published
Targeting gut dysbiosis: a new frontier in MASLD management
Shweta Sharma · Arun Pachauri · Harshal Nagar · Vishwa Thakkar · Kajal Patel
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1937809
Mini Review
Published
Generative models of living development: an interaction-centered proposal and its implications for artificial life research
Bin Yin · Xiao-Rui Wu
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1904510
Review
Published
Decoding endurance performance: integrative genomic and epigenetic insights into the molecular basis of athletic adaptation
Arij El Haddouchi · Amina Marrouh · Souad Kartti · Elmostafa El Fahime · Saber Boutayeb · Younes Chagar · Christophe Baudot · Lahcen Belyamani · Rachid Eljaoudi · Taoufiq Dakka
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1858520
Original Research
Published
Latent multimorbidity classes and antithrombotic medication distributions among patients hospitalized for bleeding after dental surgery: a retrospective study
Juliane Wagner · Johannes Heinrich Spille · Jill Flor · Zeyue Ouyang · Jonas Conrad · Christof Dörfer · Jörg Wiltfang · Hendrik Naujokat
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1917159
Review
Published
Genetic determinants of tendon and ligament injuries in athletes: a narrative review from single variants to gene-gene interactions
Amina Marrouh · Arij El Haddouchi · Souad Kartti · Elmostafa El Fahime · Saber Boutayeb · Younes Chagar · Christophe Baudot · Lahcen Belyamani · Taoufiq Dakka · Rachid Eljaoudi
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1858521
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Hypothesis and Theory
Published
The causal integration ladder: a multilevel evidence framework for therapeutic target evaluation in cervical cancer
Shishir Singh · Manyata Srivastava · Pragathi Uppada · Diksha Ameta · Aesha Singh · Monisha Banerjee · Atar Singh Kushwah
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1874355
Review
Published
Functional saturation of Earth’s habitable domains: constraints on land systems and potential in marine environments
I. Valentin Petrescu-Mag · Ioan G. Oroian · Benone Păsărin · O. Călin Safirescu · Petru Burduhos · Ioan Braşovean · Daniela Bordea · Bianca Moldovan · Tudor N. Pojar · Ioan Bănățean-Dunea · F. Camelia Oroian · Praveen Pandey
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1941138
Case Report
Published
Combined abdominal and transcranial photobiomodulation is associated with fecal microbiome restructuring: a systems microbiology pre-post case report
Gabriela N. F. Guimarães · Douglas W. Barrett · F. Gonzalez-Lima
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1920618
Original Research
Published
Covariate-adjusted AP-1 motif architecture and footprinting track olaparib-adaptive chromatin remodelling
Subhajit Dutta
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1859256
Original Research
Published
Engineering Thermobifida fusca cutinase variants for the sustainable recycling of PET from cotton-blended textiles
Neo Su · Dylan Bo Huang · Tzu-Chun Pu · Ian Cheng · Pin-Hua Chen · Chi-Cheng Hsieh · YuTing Lin · Chi Hou Ng · Ya-Shan Yu · Jakie Ting · Yu-Chuen Lai · Jason Wang
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1914536
Original Research
Published
Bidirectional network hubs: NT-genes as candidate targets for partial cancer reversal
Gabriel Gil · Rolando Perez · Augusto Gonzalez
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1868020
Hypothesis and Theory
Published
“An illustrative socio-biological cascade of the concentric model for health-bound networks: social determinants, social support and biological responses”
Michele Battle-Fisher
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1920622
Review
Published
From biological surfaces to engineered systems: how synthetic and systems biology enable biomimetic design
Btisème Bendjebour · Clément Iriart · Mathumitha Jeevakumar · William Potié · Lison Salin · Sébastien Urien · Johan Habersetzer · Urielle M’Be · Sophie Mothré · Pierre-Antoine Vigneron · Julien Grimaud
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1860815
Original Research
Published
A systems microbiology framework for reproducible multi-dataset omics integration with application to long COVID
Brigitta Varga · Marlet Martinez-Archundia · Linette E. M. Willemsen · Johan Garssen · Alejandro Lopez-Rincon
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1873899
Original Research
Published
Integrative genome-scale metabolic model of GABAergic neurons reveals metabolic signatures across the mild cognitive impairment – Alzheimer disease continuum
Andrea Angarita-Rodríguez · Johan H. Largo-González · Julián Pérez-Mejía · Daniel Balcazar · Viviana Vargas-López · Jason A. Papin · Andrés Pinzón · Janneth González
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897648
Original Research
Published
Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors
Sarah Szaffich · Valentin Just · Natalija Cvetkovic · Naila Pepic · Michael Schwendinger · Kia Katchar · Klaus K. Orlinger · Henning Lauterbach · Josipa Raguz · Katell Bidet Huang
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897043
Review
Published
Integrative multi-omics and network biology in cardiovascular disease: a systems-level framework for translational discovery
Vanesa Brecher · Vasiliki Androutsopoulou · Serge Sicouri · Basel Ramlawi · Dimitrios V. Avgerinos · Thanos Athanasiou · Dimitrios E. Magouliotis
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1897299
Review
Published
Climate-stressed crop mycobiomes as pre-harvest sentinels of human mycotoxin exposure: an AI-enabled One Health framework linking dysbiosis, exposomics, and toxicopathology
Sayandeep K. Das · Prithviraj Karak · Prachi Parvatikar
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1921729
Original Research
Published
A cellular automaton model of osteogenic differentiation reveals identifiability limits of endpoint assays
Ali Aslan Demir · Thomas Combriat · Catherine Anne Heyward · Hanna Tiainen · Aurélie Carlier · Dag Kristian Dysthe
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1872774
Original Research
Published
Microbial metacommunity dynamics associated with the cyclopoid copepod Mesocyclops hyalinus (Rehberg, 1880) in freshwater mesocosm using low-cost organic media
Rida Riyaz · Sukham Munilkumar · Na-i-sabet Dohtdong · Paramita Banerjee Sawant · Perumal Santhanam · Madhuri Pathak · S. P. Shukla · Pradeep Kumar Singh · Kenyum Lollen · Pranab Gogoi
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1845217
Review
Published
Gut microbiota-mediated biotransformation of dietary bioactive compounds: inter-individual variability, determinants, and implications for personalised nutrition
Tapash Chakraborty · Shashanka Jyoti Kashyap · Pragyan Deep Chetia · Sumona Purkayastha
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1898890
Original Research
Published
Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer
Apoorva K. A. Pai · Leona Dcunha · Athira Perunelly Gopalakrishnan · Samseera Ummar · Athira C. Rajeev · Rajesh Raju
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1788470
Original Research
Published
A machine learning framework for predictive interpretation of variants of uncertain significance in hereditary cancer
Nayeema Nizamuddin · Soham Biswas · Akshaykumar Zawar · Poonam Deshpande · Layal Yasin · Prashanth N. Suravajhala
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1828263
Original Research
Published
Female chronic social defeat stress (fem CSDS) maps synaptic, bioenergetic and metabolic proteome remodeling in the nucleus accumbens (NAc)
Shashikant Patel · Roli Kushwaha · Anushka Arvind · P. V. Anusha · Arvind Kumar · Mohammed M. Idris · Sumana Chakravarty
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1904427
Original Research
Published
Integrative functional profiling of rhizospheric and endophytic bacteria reveals Lelliottia aquatilis as a multifunctional PGPR in Himalayan ecosystems
Shikha Devi · Riya Chandel · Damini Thakur · Shweta Pathania · Simran Chauhan · Simran Simran · Nishtha Pathak · Poonam Katoch · Taniya Tyagi · Sushila Devi · Arvind Kumar Bhatt · Sveta Thakur
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1872892
Review
Published
A generative AI multi-agent framework with integrated XAI governance for cancer diagnostics: from multi-omics interpretation to lifestyle risk stratification
Chamseddine Barki · Mariem Chouchen · Afef Sediri · Halil İbrahim Ceylan · Hanene Boussi Rahmouni · Raul Ioan Muntean · Hesham R. El-Seedi · Nicola Luigi Bragazzi · Ismail Dergaa
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1892418
Review
Published
Phosphorylation dynamics of sodium-independent organic anion transporter SLCO4A1 and its role in diseases: a review
Jaytha Thomas · Suhail Subair · Althaf Mahin · Athira Perunelly Gopalakrishnan · Prathik Basthikoppa Shivamurthy · Athira C. Rajeev · Rajesh Raju
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1780024
Original Research
Published
Mapping cancer dynamics from normal tissue to malignancy using N- and T-gene expression markers
Gabriel Gil · Rolando Perez · Augusto Gonzalez
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1845582
Correction
Published
Correction: Improving DirectLiNGAM for high-dimensional microbiome data: roots screening and eBIC based model selection
Francesco Canonaco · Enzo Acerbi · Fabio Stella
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1929002
Perspective
Published
Honeybee aging as an emergent property of a self-organizing dissipative system
Radmila Čapková Frydrychová
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1874982
Review
Published
Beyond static biomarkers: systems biology and AI for decoding cancer dynamics
Subhajit Dutta · Anjana Goli
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1855016
Editorial
Published
Editorial: Big data in systems biology
Holger Husi
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1905528
Mini Review
Published
The interaction of biological network topology and mutation effects in complex trait evolution
Alexandre Gouy
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1845370
Perspective
Published
BioModels’ model of the year 2024
Rahuman S. Malik Sheriff · Hiroki Asari · Liesbet Geris · Henning Hermjakob · Karthik Raman · Blerta Shtylla · Maria Zimmermann-Kogadeeva
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1829848
Perspective
Published
The Remission Therapy Inquiry-Based Research Model (RIRM): a conceptual framework for mechanistic hypothesis generation
Pichit Suvanprakorn · Krit Pongpirul
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1835804
Original Research
Published
N-Gene and T-Gene deregulation networks: a data-driven causal framework for the analysis of gene interventions in cancer
Frank Castel · Roberto Herrero · Jean Pierre Gómez · Gabriel Gil · Augusto Gonzalez
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1861211
Original Research
Published
Design and develop a prototype fixed column using bacterial cellulose and ferric chloride for Cr(VI) removal
Uriel Fernando Carreño Sayago · Vladimir Ballesteros Ballesteros · Angelica Maria Lozano Aguilar · Jorge Luis Nisperuza
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1844304
Original Research
Published
Improving DirectLiNGAM for high-dimensional microbiome data: roots screening and eBIC based model selection
Francesco Canonaco · Enzo Acerbi · Fabio Stella
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1835323
Perspective
Published
Integrating clinical knowledge to preserve clinical coherence in health systems
Lawrence Merle Nelson
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1866901
Original Research
Published
Optimizing a carbon source based on water temperature to reduce Vibrio abundance and promote beneficial bacteria in a Penaeus vannamei shrimp biofloc system in China: a preliminary study
Abdallah Ghonimy · Zhao Chen · Laura Susana López Greco · Fernando Dyzenchauz · Jian Li
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1819518