Review
Published
A review on advances in chemical compound toxicology prediction
Ahmed Hagag · Nada A. Elsayed · Ibrahim Abdelbaky
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1974935
Library
Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 104 articles
Systematic Review
Published
Effect of different dietary patterns on patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials
Haojie Xu · Haotian Ma · Siyao Jin · Yanming Li · Shaolong Zhang · Libo Zhao
Frontiers in Nutrition
doi 10.3389/fnut.2026.1929818
Review
Published
From environmental occurrence to human exposure: multisystem toxicity, immune-relevant mechanisms, and gaps in health-risk assessment of liquid crystal monomers
Hongchi Zhang · Jingle Qiu · Zhenyu Lu · Xiangbin Zheng · Xia Huo · Xijin Xu
Frontiers in Public Health
doi 10.3389/fpubh.2026.1977975
Original Research
Published
Selective inhibition of aldosterone production modulates human adrenocortical (HAC15) cell fate
Kha Chin Long · Amnani Aminuddin · Najiah Ajlaa Ayub · Geok Chin Tan · A. Rahman A. Jamal · Nor Azian Abdul Murad · Nor Adzimah Johdi · Celso E. Gomez-Sanchez · Norlela Sukor · Morris J. Brown · Elena A. Azizan
Frontiers in Endocrinology
doi 10.3389/fendo.2026.1872432
Original Research
Published
Sex-dependent transcriptional and imaging responses to metformin in young-adult mice with SuHx-induced pulmonary arterial hypertension
Irene Fernández-Folgueral · María Jesús Sánchez-Guisado · Irati Aiestaran-Zelaia · Marta Beraza · Aitor Zubillaga-Unsain · Claudia Miranda-Pérez de Alejo · Amanda Marrero-Pérez de Alejo · Kinsey Mae Thorpe · Angela Frimpong · Rui Adão · Ian J. Holt · Jesús Ruiz-Cabello
Frontiers in Cardiovascular Medicine
doi 10.3389/fcvm.2026.1947678
Original Research
Published
Agaricia spp. recruitment failure and subsequent recovery in the wake of mass bleaching and disease outbreak on reefs of St. Thomas, US Virgin Islands
Bradley Arrington · Lindsay Dade · Deborah J. Gochfeld · Julie Beth Olson · Raphael Ritson-Williams · Erin Hollander · Tyler Burton Smith · Marilyn E. Brandt
Frontiers in Marine Science
doi 10.3389/fmars.2026.1923352
Original Research
Published
The psychological configuration of suicidal ideation in depressive disorder: an integrative and predictive approach
Sebastian Mihai Armean · Codruţa Alina Popescu · Bogdan Florin Covaliu · Bogdana Adriana Năsui · Roxana Şipoş · Romulus Dan Nicoară
Frontiers in Public Health
doi 10.3389/fpubh.2026.1958636
Original Research
Published
Study on the promoting effect of microplastic exposure on prostate cancer migration and invasion based on network toxicology and single-cell sequencing technology
Haiyang Jiang · Ying Bi · Longguo Dai · Yong Zhu · Ruikang Zhang · Chen Hu · Hong Yang · Jun Li · Chongjian Zhang · Yu Bai · Ruiqian Li
Frontiers in Oncology
doi 10.3389/fonc.2026.1973812
Original Research
Published
Cannabidiol preserves astrocyte viability and attenuates injury-induced glial stress responses across zebra finch song control nuclei
Dylan A. Marshall · Karen A. Litwa · Ken Soderstrom
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1972787
Systematic Review
Published
Forensic source classes and toxic-equivalent concentrations of polycyclic aromatic hydrocarbons in soils and sediments: a systematic review and meta-analysis
Vaibhav Sharma · Mahipal Singh Sankhla · Anuj Sharma · Kumud Kant Awasthi · Rachit Manchanda · Vishwanil Suman · Yogesh Kumar · Rupesh Gupta · Rajeev Kumar · Garima Awasthi
Frontiers in Earth Science
doi 10.3389/feart.2026.1948291
Original Research
Published
Multi-omics integration reveals the role of PFOS in sarcopenia via ESRRG and RBP4: from computational prediction to experimental validation
Xingyao Yang · Xin Wang · Shuxing Xing · Zhangzhen Du
Frontiers in Pharmacology
doi 10.3389/fphar.2026.1926144
Review
Published
Artificial intelligence - driven toxicogenomics for predictive environmental and pharmaceutical safety
Mohammed Monirul Islam · Sibghatullah Muhammad Ali Sangi · Girish Meravanige · Sreeharsha Nagaraja · Muhammad Shahzad Chohan · Md Khalid Anwer · Ashesh Gurung
Frontiers in Genetics
doi 10.3389/fgene.2026.1858338
Original Research
Published
Family physicians’ knowledge, attitudes, and practices regarding complementary and alternative medicine in Saudi Arabia: an exploratory cross-sectional study
Safaa M. Alsanosi · Asim M. Alshanberi · Aljawharah Alqathama · Majd Almech · Husna Irfan Thalib · Bandar M. Abuageelah · Ameena Manzoor · Ruwaydah Hamoud M. Alruways · Yosra Alhindi · Maram H. Alshareef
Frontiers in Health Services
doi 10.3389/frhs.2026.1837145
Original Research
Published
Reduction of Candidatus Liberibacter asiaticus titres in citrus seedlings via root-drenching application of bio-based nanoemulsions
Vitória Rodrigues Bergamo · Vítor Rodrigues Marin · Caio Felipe Cavicchia Zamunér · Lucas Miotelo · Maicon Segalla Petrônio · Henrique Ferreira
Frontiers in Agronomy
doi 10.3389/fagro.2026.1965184
Original Research
Published
Astrocyte maturation creates a stage-specific niche that instructs hippocampal neurogenesis
Evangelia Masouti · Lucía Casares-Crespo · Andreas Sagner · Arne Gessner · Martin F. Fromm · Helena Mira · Ruth Beckervordersandforth
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1966983
Review
Published
Management of fragile X-associated tremor ataxia syndrome: a review for clinicians
Deborah A. Hall · David Andrés González · Jessica Klusek · Peter K. Todd · Joan A. O’Keefe · Nell Maltman · Federica Alice Maria Montanaro · Dragana Protic · Laura Scorr · Rabia Malik · Pierpaolo Turcano · Matthew S. Meyers · Andreea Seritan
Frontiers in Neurology
doi 10.3389/fneur.2026.1870779
Brief Research Report
Published
Transcriptomic insights into loperamide-induced gastric dysmotility: RNA-seq analysis of a mouse model
Chunggeon Lee · Seung-Ju Hwang · Young-Su Yang · Bokyung Kim · Dong-Seon Kim · Daeui Park · Chang-Woo Song · Chang-Gue Son
Frontiers in Physiology
doi 10.3389/fphys.2026.1924065
Review
Published
Culture and conservation: a One Health approach to Indigenous and ancestral herptile knowledge
Ashley N. Morgan · Fortunate Mafeta Phaka · Ida Ayu Dian Kusuma Dewi · Angela Julian · Andres Santiago Carrasco-Medina · Tariq Stark · Jywateju Kayabi · Iauapuru Trumai · Lorena Dall’Ara Guimarães · María Torres-Sánchez · Debra L. Miller
Frontiers in Amphibian and Reptile Science
doi 10.3389/famrs.2026.1766675
Review
Published
Advances and applications of wearable electrochemical sensors in personalised medicine and precision agriculture: a systematic review
Vaibhav Sharma · Anuj Sharma · Raj Shukla · Mahipal Singh Sankhla · Garima Awasthi · Amanpreet Singh · Manpreet Kaur · Diksha Pathania · Sheifali Gupta · Kumud Kant Awasthi · Harsh Sable
Frontiers in Sensors
doi 10.3389/fsens.2026.1951973
Correction
Published
Correction: Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework
Marc Jacobs · Samad Goudarzi · Jan Stücke · Robin Röhm · Timo Kanninen · Tero Oinonen · Petra Ritter · Michael Schirner · Fabian Prasser · Arman Bhagwagar · Bernd Matzenbach · Hartmut Schultze · Joachim Schultze · Mathias Göschl · Henrik Matthies · Kenneth R. Evans · Moyez Dharsee · Christian Stephan · Marvin Belz · Philip Gribbon · Katja Herzog · Chester Chen · David Ruau · Ittai Dayan · Adrish Sannyasi · Dieter Kranzlmüller · Naweiluo Zhou · Jens Warfsmann · Martin Hoffmann · Rudi Schmidt · Martin Hofmann-Apitius
Frontiers in Digital Health
doi 10.3389/fdgth.2026.2006683
Original Research
Published
Instillation timing as the main determinant of aqueous humor nepafenac exposure
Angelo Macri · Annalisa Salis · Margherita Tarallo · Michele Iester · Gianluca Damonte · Francesca Mattioli
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1913752
Original Research
Published
Discovery of metabolite biomarkers for cerebral ischemia-reperfusion injury based on metabolomics: neurotoxic mechanism and functional validation of a flavopiridol -related metabolite
Zhi-guang Song · Yu-chen Liu · Zhen-lin Zhong · Shu-ting Yin · Si-si Dai · Yi-di Zeng · Cai-xing Zheng · Si-yuan Chen · Ji-yong Liu · Yan-song Liu · Si-min Peng · Shi-min Tan · Qian-ru Zeng · Hua Li · Wang-hua Liu
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1752337
Review
Published
From microplastics to nanoplastics: environmental transformation pathways, detection challenges, and health implications
Nour Alnairat · Safaa B. Hussein · Duaa Abu-Dalo · Dima Nawafleh · Sahar Farwaneh · Mohammad Assaf · Ibrahim Qahtan Al-Khaial · Haneen Waleed · Hadeel T. Al-Sinjilawi · Banan Hudaib · Rund Abu-Zurayk
Frontiers in Materials
doi 10.3389/fmats.2026.1950397
Original Research
Published
Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach
Elisavet Renieri · Achilleas Karakoltzidis · Nafsika Papaioannou · Dayna R. Schultz · Thanasis Papageorgiou · Catherine Gabriel · Ilias S. Frydas · Kévin Bernal · Xavier Coumoul · Etienne B. Blanc · Normand Podechard · Hélène Le Mentec · Charbel Touma · Sophie Langouët · Talía Boronat-Belda · Hilda Ferrero · Paloma Alonso-Magdalena · Karine Audouze · Spyros Karakitsios · Dimosthenis A. Sarigiannis
Frontiers in Toxicology
doi 10.3389/ftox.2026.1930835
Original Research
Published
Classical and intermediate monocytes and their ratios in the natural immune course of ischemic stroke
Marta Oses · María Araceli García-Torres · Cristina Serrano del Castillo · Ana Moraga · Inmaculada Navas · Marta Guillán · Ivana Zamarbide · Víctor Mora · Carolina Peña-Martínez · Fernando Ostos · Patricia Calleja · María Ángeles Moro · Alicia García-Culebras · Ignacio Lizasoain
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1889912
Review
Published
Phytocannabinoid-drug interactions: pharmacokinetic and pharmacodynamic mechanisms, clinical relevance and toxicological considerations
Diogo Alexandre Gomes · Wellyngton Vieira Eufrázio · Marcella Silva Ribeiro · Linério Ribeiro de Novais Júnior · Flávia Rigo · Patrícia de Aguiar Amaral · Antonella Campanale · Antônio Inserra · Rafael Mariano de Bitencourt
Frontiers in Toxicology
doi 10.3389/ftox.2026.1952599
Hypothesis and Theory
Published
A pragmatic workflow for integrating large language models into toxicological risk assessment
Arianna Bassan · Alexander Amberg · Maria Letizia Barreca · Paul M. Bradley · Frank Bringezu · Joyce De Paula Souza · Corinne Guicheney · Elena Lo Piparo · Simona Kovarich · Andrey Massarsky · Georgia Maundrill · Lance Molnar · Cristina Parenti · Patricia Parris · Manuela Pavan · John F. Reichard · Ron Steigerwalt · Olga Tcheremenskaia · Kenneth Unice · Christopher J. Waine · Geraldine Whelan · Angela White · Glenn J. Myatt
Frontiers in Toxicology
doi 10.3389/ftox.2026.1877128
Original Research
Published
Differential toxicity of water- and DMSO-extractable PM2.5 fractions in human alveolar organoids
Shasha Yu · Shangyao Liu · Jiajie Pan · Xinyang Guo · Shuyang Dai · Shaopeng Chen · Jie Ma
Frontiers in Toxicology
doi 10.3389/ftox.2026.1943932
Review
Published
Chronic dizziness: neuro-sensitization and psycho-sensitization
Moyan Wang · Qi Han · Xin Teng · Dingyu Liu · Zhen Yang · Huiying Li · Yingxia Yu · Wei Zhao · Ke Xiang · Li Sun
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2026.1929481
Review
Published
Contributions of aquatic organisms to understanding the vertebrate ocular lens
Mason Posner
Frontiers in Ophthalmology
doi 10.3389/fopht.2026.1900415
Original Research
Published
Combined exposure to emerging Fusarium mycotoxins produces concentration-dependent synergistic toxicity in Jurkat T cells
Chanamon Maleeratana · Phattarawadee Wattanasuntorn · Saranya Poapolathep · Imourana Alassane-Kpembi · Johanna Fink-Gremmels · Isabelle P. Oswald · Amnart Poapolathep
Frontiers in Toxicology
doi 10.3389/ftox.2026.1924250
Original Research
Published
Integrated transcriptomic and metabolomic ecotoxicity assessment of earthworms exposed to ZnO and Mn-doped ZnO nanomaterials
Henk J. van Lingen · Paraskevi Zagana · Changlin Ke · Edoardo Saccenti · Marta Baccaro · Maria I. Klapa · Zoi G. Lada · Nico W. van den Brink · Maria Suarez-Diez
Frontiers in Toxicology
doi 10.3389/ftox.2026.1927574
Original Research
Published
A single-cell atlas and Shiny-based framework for murine lung injury and remodeling
Qiuming Wang · Jixian Li · Philip J. Moos · Alessandro Venosa
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1886929
Review
Published
Microplastics in agricultural soils: sources, soil–plant interactions, ecotoxicological effects and food security concerns
Deepali Rustagi · Kunal · Rohit Kumar · Pankaj Kumar · Atin Kumar · Rajeev · Jungjit Critykar · Debasis Mitra · Mahendru Kumar Gautam · Vishnu D. Rajput · Caleb Ayomide Babatunde
Frontiers in Soil Science
doi 10.3389/fsoil.2026.1899490
Review
Published
Carbon dots in cancer therapy: a novel approach to targeted drug delivery and reduced toxicity in gallbladder cancer
Mahvish Fatima · Warda Parveen · Norah M. Almaneai · Attalla F. El-kott · Mohammed A. AlShehri · Waleed Eltantawy · Nosheen Kanwal · Zaheera Saadia
Frontiers in Chemistry
doi 10.3389/fchem.2026.1899601
Original Research
Published
Fungal contamination, mycotoxins, histamine, and allergen-related immunoreactivity in edible insects and insect-fortified complementary foods
Maryam Imbumi · Sheila Okoth · Kris Audenaert · Hans De Steur · Xavier Gellynck · Chrysantus Mbi Tanga · Sarah De Saeger · Judith Kimiywe · Katleen Raes
Frontiers in Fungal Biology
doi 10.3389/ffunb.2026.1798430
Review
Published
Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities
John S. Kendrick · David A. Shaw · Marie Jourdain · Claudia Senn · Helen Beyer · Fiona R. Sewell
Frontiers in Toxicology
doi 10.3389/ftox.2026.1854281
Original Research
Published
A multi-residue electrostatic clamp in HIV-1 CRF01_AE Tat underlies high-affinity engagement with NMDA and hDAT receptors
Shaughn Dominic M. Padon · Ana Joy P. Lozano
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1923721
Case Report
Published
Combined abdominal and transcranial photobiomodulation is associated with fecal microbiome restructuring: a systems microbiology pre-post case report
Gabriela N. F. Guimarães · Douglas W. Barrett · F. Gonzalez-Lima
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1920618
Review
Published
Algal biochar for metalloid removal: from waste algae to cleaner water
Vaibhav Sharma · Raj Shukla · Mahipal Singh Sankhla · Kumud Kant Awasthi · Rachit Manchanda · Yogesh Kumar · Rupesh Gupta · Garima Awasthi
Frontiers in Chemical Engineering
doi 10.3389/fceng.2026.1921327
Perspective
Published
The plasma-plastic paradox: breaking down plastics, building up risk?
Joana Antunes · José Gonçalves · João Pequeno
Frontiers in Ocean Sustainability
doi 10.3389/focsu.2026.1923882
Original Research
Published
A practical approach for regulatory acceptance of virtual control groups: vehicle pooling and biological relevance assessment
Jiwon Kim · Yoongi Kim · Daeui Park · Sang Kyum Kim · Myung-Gyun Kang
Frontiers in Toxicology
doi 10.3389/ftox.2026.1888158
Systematic Review
Published
Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review of in vitro toxicological evidence
Laura Maria Messina · Maria Concetta Scuto · Gabriella Lupo · Cinzia Maria Grazia Lombardo · Caterina Ledda · Angela Trovato Salinaro
Frontiers in Toxicology
doi 10.3389/ftox.2026.1908508
Original Research
Published
Comparative in vitro safety assessments of synthetized and plant-derived cannabidiol (CBD), and pharmacokinetics of synthetized CBD: evidence of similar toxicological profiles and accumulation upon repeated oral administration
E. T. Wong · D. Bovard · W. K. Schlage · W. Xia · H. Isa · O. Sirbu · A. R. Kolli · G. N. Nikolajsen · S. S. Jensen · J. Ho · B. Phillips · J. Hoeng
Frontiers in Toxicology
doi 10.3389/ftox.2026.1844643
Review
Published
Pollutants regulate changes in pathological markers of neurodegenerative diseases: a new perspective in environmental toxicology
Xingbo Kou · Qianqian Hu · Yibo Kou · Dinghao An
Frontiers in Toxicology
doi 10.3389/ftox.2026.1814795
Review
Published
Rewriting paracelsus: linking chemical assessment to public health
Ana Fernandez-Agudo · María del Carmen González-Caballero · Jose V. Tarazona
Frontiers in Toxicology
doi 10.3389/ftox.2026.1872816
Editorial
Published
Editorial: The safety assessment of novel foods and new nutrient sources
Luisa Pozzo · Maria Glymenaki
Frontiers in Toxicology
doi 10.3389/ftox.2026.1965747
Mini Review
Published
Toxicology of caffeine poisoning: molecular mechanisms, toxicokinetic profiles, and clinical implications
Antonia Socias · Rafael Blancas
Frontiers in Toxicology
doi 10.3389/ftox.2026.1933375