Perspective
Published
Advances in enhanced sampling simulations of G-protein-coupled receptors
Keya Joshi · Victor Ayo Adediwura · Yinglong Miao
Frontiers in Chemical Biology
doi 10.3389/fchbi.2026.1943336
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Articles
Every article on Frontiers is peer reviewed, permanently archived and free to read.
Showing 213 articles
Methods
Published
Study protocol for microneurographic investigation of nociceptor sensitisation in fibromyalgia syndrome (MICRO-FMS)
Elise A. Ajay · Faris Khan · Atanu Bhattacharjee · Anthony E. Pickering · James P. Dunham
Frontiers in Pain Research
doi 10.3389/fpain.2026.1911020
Correction
Published
Correction: Selecting medical research data platforms for translational biomedical research: a five-tier overview and requirement-weighted assessment framework
Marc Jacobs · Samad Goudarzi · Jan Stücke · Robin Röhm · Timo Kanninen · Tero Oinonen · Petra Ritter · Michael Schirner · Fabian Prasser · Arman Bhagwagar · Bernd Matzenbach · Hartmut Schultze · Joachim Schultze · Mathias Göschl · Henrik Matthies · Kenneth R. Evans · Moyez Dharsee · Christian Stephan · Marvin Belz · Philip Gribbon · Katja Herzog · Chester Chen · David Ruau · Ittai Dayan · Adrish Sannyasi · Dieter Kranzlmüller · Naweiluo Zhou · Jens Warfsmann · Martin Hoffmann · Rudi Schmidt · Martin Hofmann-Apitius
Frontiers in Digital Health
doi 10.3389/fdgth.2026.2006683
Original Research
Published
Instillation timing as the main determinant of aqueous humor nepafenac exposure
Angelo Macri · Annalisa Salis · Margherita Tarallo · Michele Iester · Gianluca Damonte · Francesca Mattioli
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1913752
Original Research
Published
Focused ultrasound increases Lucifer Yellow transport across hCMEC/D3 endothelial monolayers
Sam Bleker · Kyra-Elisa M. Redeker · Gerrit Meußler · Ralf Brinkmann · Jürgen Brockmöller · Christoph Russmann
Frontiers in Acoustics
doi 10.3389/facou.2026.1968185
Original Research
Published
Mechanism of luteolin in treating chronic heart failure by regulating HIF-1 signaling pathway-mediated mitochondrial damage to inhibit cardiomyocyte apoptosis
Weiqi Shi · Zhide Zhu · Junshen Lu · Meiling Tang · Yan Pang · Zhilin Peng · Jie Lu · Puwei Huang · Shanyun Zou · Jiaji Wu · Yarou Tu · Chunmei Fan · Yuyun Gan · Lihui Hu · Qi Lin · Liuqin Qin · Rusheng Shi · Fei Zhong · Yuxuan Shen · Jianqi Lu
Frontiers in Cell and Developmental Biology
doi 10.3389/fcell.2026.1977166
Original Research
Published
Focused ultrasound increases Lucifer Yellow transport across hCMEC/D3 endothelial monolayers
1. Faculty of Engineering and Health, HAWK University of Applied Sciences and Arts Hildesheim/Holzminden/Göttingen, Göttingen, Germany. · 2. Institute of Clinical Pharmacology, University Medical Center Göttingen, Göttingen, Germany. · 3. Medical Laser Center Lübeck, Lübeck, Germany. · 4. Institute of Biomedical Optics, University of Lübeck, Lübeck, Germany.
Frontiers in Acoustics
doi 10.3389/facou.2026.1897567
100 views
Original Research
Published
Remote control of wildtype zebrafish optomotor response with a photoswitchable drug
Luisa Camerin · Joaquín Martínez-Tambella · Gregor Schuhknecht · Vickie M. Wang · Kumaresh Krishnan · Paula Pflitsch · Florian Engert · Pau Gorostiza
Frontiers in Behavioral Neuroscience
doi 10.3389/fnbeh.2026.1916443
Original Research
Published
Bacterial actin MreB as a new antibiotic target
Emőke Bódis · Beáta Longauer · András Lukács · Tamás Huber · Miklós Nyitrai · Géza Makkai · Tibor Jánosi · Rita Börzsei · Csaba Hetényi · Zoltán Gazdag · Szilvia Barkó
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1912759
Original Research
Published
Xeno-free production of lentiviral particles: implementing hPL as FBS replacement in cell culture
Mariana Soares Guedes · Marnie Cole · Daniela Yildiz
Frontiers in Toxicology
doi 10.3389/ftox.2026.1903400
Original Research
Published
Exploring the potential targets and possible mechanisms of Shenqi Fuzheng Injection in the treatment of cancer-associated muscle wasting based on network pharmacology
Chen Liu · Ling Cheng · Wenfeng Ye · Lina Zhang
Frontiers in Genetics
doi 10.3389/fgene.2026.1876819
Review
Published
Strategy for early diagnosis of pancreatic cancer
Ravi Kumar Sharma · Alpa Singh · Gaurav Sharma · Saurabh Dawra · Surinder Singh Rana
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1731223
Original Research
Published
Yaobitong plus celecoxib for low back pain: a Chinese multicenter cohort and network pharmacology study
Huahui Gong · Chenxing Lu · Zhanghao Guo · Min Wu · Di Wu · Xu Zheng · Lei Liu · Fenghua Chen · Changyou Li
Frontiers in Pain Research
doi 10.3389/fpain.2026.1915365
Original Research
Published
Synovial fluid-derived extracellular vesicles modulate joint cell function in osteoarthritis
Alvaro Compañ · Vittoria Carrabs · María Luisa Ferrándiz · Antonio Silvestre · Ignacio Muñoz · María Carmen Carceller · María Isabel Guillén
Frontiers in Aging
doi 10.3389/fragi.2026.1894052
Review
Published
Gut microbiota–cancer crosstalk: emerging molecular targets for personalized cancer treatment- a comprehensive review
Pooja Negi · Arpita Upreti · Preeti Budhlakoti · Amit Kumar Sen · Mitali Danu · Sumit Tewari · Nirmal Joshi · Deepak Chandra Joshi
Frontiers in Molecular Biosciences
doi 10.3389/fmolb.2026.1924197
Original Research
Published
Classical and intermediate monocytes and their ratios in the natural immune course of ischemic stroke
Marta Oses · María Araceli García-Torres · Cristina Serrano del Castillo · Ana Moraga · Inmaculada Navas · Marta Guillán · Ivana Zamarbide · Víctor Mora · Carolina Peña-Martínez · Fernando Ostos · Patricia Calleja · María Ángeles Moro · Alicia García-Culebras · Ignacio Lizasoain
Frontiers in Neuroscience
doi 10.3389/fnins.2026.1889912
Review
Published
MeCP2 functions as a DNA methylation reader in immune homeostasis and cancer
Grace C. Stroman · Clara Mellows · Kevin Pruitt
Frontiers in Epigenetics and Epigenomics
doi 10.3389/freae.2026.1917394
Original Research
Published
Structural, biomedical and metal-ion sensing properties of the eco-friendly synthesized CrVO 4 nanoparticles using Saussurea obvallata flower extract
Diya Patel · Mamta Patil · Kajalben Patel · Yogita Abhale · Mahmoud Mirzaei · Majid S. Jabir · Suresh Ghotekar
Frontiers in Materials
doi 10.3389/fmats.2026.1914758
Review
Published
Phytocannabinoid-drug interactions: pharmacokinetic and pharmacodynamic mechanisms, clinical relevance and toxicological considerations
Diogo Alexandre Gomes · Wellyngton Vieira Eufrázio · Marcella Silva Ribeiro · Linério Ribeiro de Novais Júnior · Flávia Rigo · Patrícia de Aguiar Amaral · Antonella Campanale · Antônio Inserra · Rafael Mariano de Bitencourt
Frontiers in Toxicology
doi 10.3389/ftox.2026.1952599
Hypothesis and Theory
Published
A pragmatic workflow for integrating large language models into toxicological risk assessment
Arianna Bassan · Alexander Amberg · Maria Letizia Barreca · Paul M. Bradley · Frank Bringezu · Joyce De Paula Souza · Corinne Guicheney · Elena Lo Piparo · Simona Kovarich · Andrey Massarsky · Georgia Maundrill · Lance Molnar · Cristina Parenti · Patricia Parris · Manuela Pavan · John F. Reichard · Ron Steigerwalt · Olga Tcheremenskaia · Kenneth Unice · Christopher J. Waine · Geraldine Whelan · Angela White · Glenn J. Myatt
Frontiers in Toxicology
doi 10.3389/ftox.2026.1877128
Mini Review
Published
From dynamic condensates to pathological assemblies: the phase behavior of tau and α -synuclein
Suelen Camargo · Kevin Novelo · Scott D. Ryan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1965177
Review
Published
Black boxes and petri dishes: AI models for antimicrobial pharmacokinetics, drug properties, and resistance
Jacob K. McPherson · Surbhi Sharma · Biswajit Mishra · Fadi Shehadeh · Eleftherios Mylonakis
Frontiers in Bacteriology
doi 10.3389/fbrio.2026.1926678
Original Research
Published
Novel chitosan-encapsulated ZnO NPs@Subtilisin: enzyme immobilized as next-generation nanoplatform for antimicrobial and anticancer control
Rua J. Kadhim · Majid S. Jabir · Ghassan M. Sulaiman · Uday M. Nayef · Suresh Ghotekar
Frontiers in Materials
doi 10.3389/fmats.2026.1922253
Review
Published
Chronic dizziness: neuro-sensitization and psycho-sensitization
Moyan Wang · Qi Han · Xin Teng · Dingyu Liu · Zhen Yang · Huiying Li · Yingxia Yu · Wei Zhao · Ke Xiang · Li Sun
Frontiers in Integrative Neuroscience
doi 10.3389/fnint.2026.1929481
Perspective
Published
Peering beyond the fourth wall: should protein quaternary structure be a state space?
Daniela Diana · Yimon Aye · Marcus J. C. Long
Frontiers in Biophysics
doi 10.3389/frbis.2026.1923311
Perspective
Published
Bioaminergic signaling in parasitic flatworms: a perspective for linking GPCRs to behavior and drug discovery
Erika Bistran · M. Evelyn Carpenter · Daniel J. Sprague
Frontiers in Parasitology
doi 10.3389/fpara.2026.1933406
Original Research
Published
Systemic responses to intravenous rAAV administration in boys with Duchenne muscular dystrophy
Brooke E. Harris · Brooke M. Seldin · Sam C. Towne · Orinda R. Hobson · Eli Zerpa · Victor Prima · H. Lee Sweeney · David W. Hammers
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1953867
Original Research
Published
Combined exposure to emerging Fusarium mycotoxins produces concentration-dependent synergistic toxicity in Jurkat T cells
Chanamon Maleeratana · Phattarawadee Wattanasuntorn · Saranya Poapolathep · Imourana Alassane-Kpembi · Johanna Fink-Gremmels · Isabelle P. Oswald · Amnart Poapolathep
Frontiers in Toxicology
doi 10.3389/ftox.2026.1924250
Original Research
Published
A single-cell atlas and Shiny-based framework for murine lung injury and remodeling
Qiuming Wang · Jixian Li · Philip J. Moos · Alessandro Venosa
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1886929
Editorial
Published
Editorial: Biomarkers and aging: new insights for precision medicine
Oluwafemi Gabriel Oluwole · Paulo Adriano Schwingel
Frontiers in Aging
doi 10.3389/fragi.2026.1987600
Original Research
Published
The aryl hydrocarbon receptor is expressed in non-sensory cells in the cochlea and regulates hair cell survival
Sujata Pandey · Brandon C. Cox
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1943479
Review
Published
Trends in micro and nanoencapsulation of various plant-based bioactive compounds for enhanced biological activities: a review
Anita Rani Gill · Pooja Sharma · Priyanka Siwach · Vivek Kumar Garg · Madhura Shirishkumar Bhosale · Ranjay Kumar Choudhary
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1839002
Review
Published
Novel bioactive compounds in the treatment of osteoporosis: chemistry-driven discovery from preclinical validation to clinical translation
Honghui Fan · Songtao Jin
Frontiers in Chemistry
doi 10.3389/fchem.2026.1917991
Original Research
Published
3-hydroxy-3-methylbutyrate (3H3MB) suppresses glioma growth and extends survival in mice
Rizwan Khan · Xingzi Lin · Francesco Marrocco · Ottavia Giampaoli · Alice Reccagni · Javeria Maqbool · Fabio Sciubba · Adriano Patriarca · Michele De Rosa · Alfredo Miccheli · Gabriele Favaretto · Fabrizio Antonangeli · Cristina Limatola · Giuseppina D’Alessandro
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1917452
Original Research
Published
Identification of natural TLR4 modulators through network pharmacology and molecular modeling in SARS-CoV-2 Acinetobacter baumannii co-infection
Mebarka Ouassaf · Shafi Ullah Khan · Kannan R. R. Rengasamy · Nada S. Alhaggass · Bader Y. Alhatlani
Frontiers in Chemistry
doi 10.3389/fchem.2026.1916568
Review
Published
The future directions of CAR-T Cell therapy: unlocking the potential of immunotherapy in cancer treatment
Angel Alberto Justiz-Vaillant · Sachin Soodeen · Rodolfo Arozarena-Fundora · Patrick Eberechi Akpaka · Chandrashekhar Unakal
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1931159
Original Research
Published
QSPR analysis using stress sum based topological indices for predicting physicochemical properties of Hodgkin lymphoma drugs
A Sivaranjani · K Bharani Dharan · S Radha
Frontiers in Chemistry
doi 10.3389/fchem.2026.1936029
Original Research
Published
ALDH1/2 deficiency modulates dieldrin-induced dopaminergic neurodegeneration and reactive glial morphometry in male mice
Omar A. Yanouri · Adam J. Schuller · Savannah M. Rocha · Aidan M. Briggs · Paul A. Martinez · Elizabeth Fernandez · Randy Strong · Xueshu Li · Hans-Joachim Lehmler · Jonathan A. Doorn · Ronald B. Tjalkens
Frontiers in Toxicology
doi 10.3389/ftox.2026.1888799
Perspective
Published
Tregs and persistent P. gingivalis colonisation: a plausible mechanism for cardiovascular risk in edentulism
Jelena Roganović
Frontiers in Oral Health
doi 10.3389/froh.2026.1895121
Review
Published
Sublingual allergen immunotherapy: evidence from randomized trials, real-world studies and meta-analyses
Giovanni Paoletti · Nicolò Valli · Danilo Di Bona · Giulia Anna Maria Luigia Costanzo · Andrea Giovanni Ledda · Stefano Del Giacco · Mattia Giovannini · Francesco Catamerò · Francesca Mori · Giuseppe Guida · Fabio Luigi Massimo Ricciardolo · Francesca Bertolini · Remo Poto · Corrado Pelaia · Gilda Varricchi · Giorgio Walter Canonica · Enrico Heffler
Frontiers in Allergy
doi 10.3389/falgy.2026.1940709
Review
Published
Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities
John S. Kendrick · David A. Shaw · Marie Jourdain · Claudia Senn · Helen Beyer · Fiona R. Sewell
Frontiers in Toxicology
doi 10.3389/ftox.2026.1854281
Original Research
Published
A multi-residue electrostatic clamp in HIV-1 CRF01_AE Tat underlies high-affinity engagement with NMDA and hDAT receptors
Shaughn Dominic M. Padon · Ana Joy P. Lozano
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1923721
Original Research
Published
Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish ( Danio rerio )
Rawlie Prince · Tobin Steman · Ethan V. Hagen · Andréa L. Johnson · Yanbo Zhang · Trevor J. Hamilton
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1924496
Case Report
Published
Combined abdominal and transcranial photobiomodulation is associated with fecal microbiome restructuring: a systems microbiology pre-post case report
Gabriela N. F. Guimarães · Douglas W. Barrett · F. Gonzalez-Lima
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1920618
Original Research
Published
Baseline PTSD and depressive symptoms predict multidimensional recovery after combat-related transtibial amputation: a prospective cohort study
Iryna Halabitska · Iryna Kamyshna · Mykhailo Buchynskyi · Pavlo Petakh · Oleksandr Kamyshnyi
Frontiers in Rehabilitation Sciences
doi 10.3389/fresc.2026.1891994
Review
Published
Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder
Kazuhiko Yamamuro · Takahira Yamauchi · Manabu Makinodan
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1915506
Review
Published
Control first, tolerance second: biologics as enablers of allergen immunotherapy in severe allergic asthma
B. Jentzsch · A. Hoheisel · K. Gashynova · S. Fähndrich · B. C. Frye · J. A. Alvarado Castillo · S. Müller · I. Cherrez-Ojeda · D. Stolz
Frontiers in Allergy
doi 10.3389/falgy.2026.1942188
Original Research
Published
Cryopreservation of human cortical organoids using vitrification
Kyle Stokes · Sandra Mojica-Perez · Samantha Jacobs · Joy Huang · Shivanshi Vaid · Yukun Yuan · Caroline A. Pearson · Daniel Montes · Andrew Tidball · Debora VanHeyningen · Jonathan Gaillard · Louis T. Dang · Margaret Elizabeth Ross · Lori L. Isom · Michael Uhler · Wei Niu · Jack M. Parent
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1913908