Review
Published
Chronic pain in the aging adult with sickle cell disease
Keesha Powell-Roach · Ugochi O. Ogu
Frontiers in Pain Research
doi 10.3389/fpain.2026.1907108
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Showing 691 articles
Review
Published
The impact of deep learning and omics data in transforming precision therapy for brain cancer
Sana Munquad · Anam Upadhyay · Asim Bikas Das
Frontiers in Bioinformatics
doi 10.3389/fbinf.2026.1811813
Review
Published
GPCR signaling systems facilitate precision interventions for multi-oncology therapy
Ashley Del Pozo · Mia Pardo · Tabitha Boeringer · Carter J. Craig · Ramzia Sorathia · Madeline Millican · Stuart Maudsley
Frontiers in Systems Biology
doi 10.3389/fsysb.2026.1940022
Original Research
Published
Active targeting towards bone cancer and metastases by pamidronate-bridged dinuclear platinum(II) complexes
Anna Maria Di Cosola · Alessandra Barbanente · Luisa D’Anna · Simona Rubino · Alessio Terenzi · Mauro Niso · Nicola Margiotta
Frontiers in Chemistry
doi 10.3389/fchem.2026.1945537
Review
Published
Transport phenomena in polymeric nanoparticle drug delivery systems: linking soft-matter design to biological performance
Samson Oluwabamise Dada · Adegboyega Daniel Osifuwa · Ifeoluwa Deborah Boyede
Frontiers in Soft Matter
doi 10.3389/frsfm.2026.1931284
Systematic Review
Published
Interventions for bleaching-induced tooth sensitivity: an umbrella review
Madina A. Kurmanalina · Zhanar G. Tankibayeva · Togzhan B. Sagimbayeva · Elnara K. Ismagulova · Assylzhan M. Messova · Amin Tamadon
Frontiers in Oral Health
doi 10.3389/froh.2026.1927686
Original Research
Published
Longitudinal trends in antimicrobial resistance phenotypes in Pseudomonas aeruginosa: a seven-year study
Wael A. Alghamdi · Khalid M. Orayj · Ahmed R. N. Ibrahim · Marim A. Abdelsalam · Abdullah M. Alshehri
Frontiers in Antibiotics
doi 10.3389/frabi.2026.1912287
Review
Published
Non-neoplastic histiocytic proliferations in bone marrow: a case series of uncommon morphologic findings
Melissa Ha · Shafagh Parsazad · Luke T. Dang · Elham Vali Betts · Denis M. Dwyre · Ananya Datta Mitra
Frontiers in Hematology
doi 10.3389/frhem.2026.1939019
Original Research
Published
Low prevalence of Plasmodium falciparum pfhrp 2 and pfhrp 3 gene deletions in archived samples collected before and after nationwide malaria-RDT rollout in Kenya
Martha N. Kivecu · Victor Mobegi · Cavin Mgawe · Brenda M. Kania · Gladys C. Chemwor · Raphael O. Okoth · Edwin W. Mwakio · George Obiero · Jennifer M. Mutisya · Jackline A. Juma · Agnes C. Cheruiyot · Benjamin H. Opot · Amanda L. Roth · Bernhards R. Ogutu · Dennis W. Juma · Lynette Isabella Ochola-Oyier · Ben Andagalu · Hoseah M. Akala
Frontiers in Epidemiology
doi 10.3389/fepid.2026.1817539
Systematic Review
Published
Comparative outcomes of advanced medical rescue therapies in steroid-refractory acute severe ulcerative colitis: a systematic review and network meta-analysis
Mohamad Yousef Alabdallat · Omar Al Ta’ani · Tarek Bakain · Ahmad Al-Dwairy · Mohammad Ghannam · Abdulrahman Atasi · Fares Mashal · Khaled Moghib · Nader Bakheet · Javed G. Jagroo · Rohan Hehr · Ahmed Salem · Derrick Cheung
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1937925
Original Research
Published
The aryl hydrocarbon receptor is expressed in non-sensory cells in the cochlea and regulates hair cell survival
Sujata Pandey · Brandon C. Cox
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1943479
Original Research
Published
Quality evaluation of a traditional Chinese medicine compound preparation containing Rhodiola rosea, Astragalus membranaceus, and Carthamus tinctorius
Zhisen Wang · Sisi Guo · Jun Chen · Lu Wang · Huicong Zhang · Xiaocan Cui · Bingling Zhao · Shihui Ge · Sai Li · Mengliang Zhu · Peipei Xing
Frontiers in Analytical Science
doi 10.3389/frans.2026.1777096
Review
Published
Microelectrode arrays: from electrophysiology to integrated cancer treatment induced cardiotoxicity assessment
Neda Karami · Sebastian Knafl · Heinz D. Wanzenboeck · Sonia Prado-López
Frontiers in Electronics
doi 10.3389/felec.2026.1886715
Original Research
Published
Unraveling skeletal muscle senescence in an in vitro cell culture model
Kayo Moreira Bagri · Morgana Teixeira Lima Castelo-Branco · Claudia Mermelstein
Frontiers in Aging
doi 10.3389/fragi.2026.1866906
Original Research
Published
Approval lag and loss for biologic-device combination products in Japan and the United States
Makiko Mochizuki · Hideki Maeda
Frontiers in Medical Technology
doi 10.3389/fmedt.2026.1924169
Original Research
Published
A novel minimally humanized mouse model of aniridia for preclinical evaluation of CRISPR gene editing strategies
Seyedeh Zeinab Mirjalili Mohanna · Andrea J. Korecki · Pardis Kazemian · Tess C. Lengyell · Bethany A. Adair · Blair R. Leavitt · Elizabeth M. Simpson
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1910209
Review
Published
Novel bioactive compounds in the treatment of osteoporosis: chemistry-driven discovery from preclinical validation to clinical translation
Honghui Fan · Songtao Jin
Frontiers in Chemistry
doi 10.3389/fchem.2026.1917991
Systematic Review
Published
Targeted therapies in systemic lupus erythematosus: mechanistic insights and clinical evidence from phase II and III trials
João Francisco Abrantes · Marina Dueñas-Ochoa · Roni Meidan · David Isenberg
Frontiers in Lupus
doi 10.3389/flupu.2026.1829480
Frontiers in Science Lead Article
Published
Aging rate indicators and the search for anti-aging drugs
Steven N. Austad · Matt Kaeberlein · Richard A. Miller
Frontiers in Science
doi 10.3389/fsci.2026.1821393
Systematic Review
Published
Predictive accuracy of peptide–target interaction models in drug discovery: a systematic review and meta-analysis
William J. Waldock · Ahmad Guni · Ara Darzi · Cesar de la Fuente-Nunez · Hutan Ashrafian
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1894745
Original Research
Published
A novel approach to HPV16 VLP construction and production with improved accessibility and particle sorting potential
Morgan Williamson · Caleb Boren · Rahul Kumar · Lauren Gollahon
Frontiers in Molecular Medicine
doi 10.3389/fmmed.2026.1941186
Systematic Review
Published
Research hotspots and emerging trends of macrophages in peripheral nerve injury: a bibliometric and visualization analysis
Guohua Jiang · Renkun Huang · Kewen Wang · Yuchang Gui · Yun Tang · Guiyang Jiang · Yijun Liu · Jianwen Xu
Frontiers in Cellular Neuroscience
doi 10.3389/fncel.2026.1893849
Review
Published
Carbon dots in cancer therapy: a novel approach to targeted drug delivery and reduced toxicity in gallbladder cancer
Mahvish Fatima · Warda Parveen · Norah M. Almaneai · Attalla F. El-kott · Mohammed A. AlShehri · Waleed Eltantawy · Nosheen Kanwal · Zaheera Saadia
Frontiers in Chemistry
doi 10.3389/fchem.2026.1899601
Review
Published
Next-generation nanomedicine for cancer therapy: advances, challenges, and future perspectives
Biswajit Mohanty · Puja Saikia · Piyush Pandey · Chira R. Bhattacharjee
Frontiers in Chemistry
doi 10.3389/fchem.2026.1920337
Systematic Review
Published
Role of prokinetic drugs prior to endoscopy in acute upper gastrointestinal bleeding: a systematic review and meta-analysis
Mohamad Yousef Alabdallat · Tarek Bakain · Abdulrahman Atasi · Omar A. Oudit · Mohammad Ghannam · Zaid AlRashid · Khaled Moghib · Emeka Stanley Obi · Muhammad Sarfaraz · Chidiebele Emmanuel Omaliko · Derrick Cheung
Frontiers in Gastroenterology
doi 10.3389/fgstr.2026.1930145
Original Research
Published
Roles of community drug distributors in health and development activities post-onchocerciasis elimination in Uganda
Stella Neema · John Bosco Asiimwe · Jenna E. Coalson · Lauri Bernard · Edridah Muheki · Harriet Sengendo · Gregory S. Noland
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1912280
Systematic Review
Published
An updated evidence-informed framework for dental sedation: drugs, routes, patient selection, monitoring, and emergency preparedness
Giath Gazal · Mohammad Zakaria Nassani · Sam Thomas Kuriadom · Kusai Baroudi
Frontiers in Oral Health
doi 10.3389/froh.2026.1915718
Original Research
Published
Overcoming delivery barriers of large all-in-one CRISPR/Cas9 plasmids using lysine-based lipid nanoparticles
Wenhan Sung · Tianshu Li · Shinji Takeoka
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1888079
Review
Published
Copper nanoparticles and their future in drug delivery and anticancer therapy
Keykavous Parang · Rajesh Vadlapatla · Cassia Charles · Kimberly Tang · Trang Nguyen · Amir Nasrolahi Shirazi · Ajoy Koomer
Frontiers in Nanotechnology
doi 10.3389/fnano.2026.1906191
Original Research
Published
Corifollitropin alfa versus daily recombinant FSH for ovarian stimulation in women of advanced maternal age: a cost-minimization analysis in an out-of-pocket setting
G. N. Cecchino · B. R. Carvalho · Y. Ramires · R. L. P. Bueno · L. A. Lucio · V. P. Santana
Frontiers in Reproductive Health
doi 10.3389/frph.2026.1939114
Mini Review
Published
Menopause-associated gut microbiome remodeling and pharmacomicrobiomics: emerging mechanisms influencing drug response
Susanne B. Haga
Frontiers in Microbiomes
doi 10.3389/frmbi.2026.1953547
Original Research
Published
Inhibition of Plasmodium DNA double strand repair by the combined action of 17-AAG and ML216
Km Tanishka · Wahida Tabassum · Deepak Kumar Rout · Maria Mukherjee · Mrinal Kanti Bhattacharyya
Frontiers in Parasitology
doi 10.3389/fpara.2026.1896831
Original Research
Published
Chemical inhibition of α-mannosidase in S. mansoni schistosomula leads to reshaped N-glycosylation associated with developmental alterations
Eleonore B. Kuhlemaijer · Tom Veldhuizen · Quirine C. A. Hoekstra · Jinthe A. Umbach · Mathijs J. Niezen · Josephine E. Forde-Thomas · Gabriel Rinaldi · Karl F. Hoffmann · Angela van Diepen · Cornelis H. Hokke
Frontiers in Parasitology
doi 10.3389/fpara.2026.1930872
Brief Research Report
Published
R2Tg retrotransposon mediated targeted integration of exogenous genes into the 28S rDNA locus in mammalian cell lines for PKU gene therapy
Xiuyuan Wang · Ziqi Wen · Rongjun Xu · Wenjing Shi · Yiling Long · Xingri Zhan · Rui Su · Jia Fei · Yumin Li
Frontiers in Genome Editing
doi 10.3389/fgeed.2026.1893815
Original Research
Published
QSPR analysis using stress sum based topological indices for predicting physicochemical properties of Hodgkin lymphoma drugs
A Sivaranjani · K Bharani Dharan · S Radha
Frontiers in Chemistry
doi 10.3389/fchem.2026.1936029
Original Research
Published
Artificial intelligence modeling of small molecule pharmaceutical solubility in supercritical fluid and comparative analysis under temperature and pressure variations
Haolin Wu · Hadil Faris Alotaibi · Ahmed Salah Fahem · Saeed Shirazian
Frontiers in Chemistry
doi 10.3389/fchem.2026.1947884
Original Research
Published
Exploratory scaffold hopping strategies led to identification of novel histamine H 3 and H 4 receptor ligands
Flávia B. Lopes · Denise Mönnich · Gustavo A. B. Fernandes · Steffen Pockes · João Paulo S. Fernandes
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1944403
Review
Published
Aging, the microbiota–gut–brain axis, and late-life epilepsy: a hypothesis-driven review
Yingsi Cao · Huiying Li · Minzheng Xu · Yuting Teng
Frontiers in Molecular Neuroscience
doi 10.3389/fnmol.2026.1861519
Original Research
Published
Identifying implementation units that would benefit from alternative treatment strategies to accelerate the elimination of onchocerciasis transmission in Africa
Aditya Ramani · Matthew A. Dixon · Martin Walker · Raiha Browning · Evandro Konzen · Simon E. F. Spencer · Claudio Fronterre · Maria-Gloria Basáñez
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1900555
Original Research
Published
Nationwide epinephrine auto-injector dispensing in Greece: a drug-utilization study providing insights into anaphylaxis epidemiology and emergency-treatment preparedness
George N. Konstantinou
Frontiers in Allergy
doi 10.3389/falgy.2026.1906574
Review
Published
Advances in biogenic nanoparticles: synthesis pathways and emerging applications
Anil Punetha · Mamta Kharkwal · Aneeta Kharkwal · Gunjan Purohit
Frontiers in Chemical Engineering
doi 10.3389/fceng.2026.1895789
Review
Published
Nanomedicine against antimicrobial resistance: mechanistic insights and next-generation therapeutic potential
Vishal L. Handa · Benedict B. Vyas · Abhishek Padhi · Ashwini Agarwal · B. R. M. Vyas
Frontiers in Chemistry
doi 10.3389/fchem.2026.1915145
Review
Published
Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities
John S. Kendrick · David A. Shaw · Marie Jourdain · Claudia Senn · Helen Beyer · Fiona R. Sewell
Frontiers in Toxicology
doi 10.3389/ftox.2026.1854281
Review
Published
Zinc oxide nanoparticles against Candida: mechanistic pathways, synergistic potentials, and biocompatibility challenges in the era of antimicrobial resistance
Binaya Krushna Sahu · Tapan Kumar Mohanta · Mahesh Chandra Sahu · Sujogya Kumar Panda
Frontiers in Antibiotics
doi 10.3389/frabi.2026.1933663
Original Research
Published
Probing the activity of BM212, an antimycobacterial, and its derivatives against multiple life cycle stages of Plasmodium falciparum
Benedetta Salvucci · Mariëtte van der Watt · Chiara Tammaro · Michela Guida · Lucrezia Pantaleo · Janette Reader · Tayla Rabie · Sizwe Tshabalala · Mariska Naude · Natanya Venter · Tyrick Welcome · Erica Erlank · Lizette L. Koekemoer · Mariangela Biava · Lyn-Marié Birkholtz · Giovanna Poce
Frontiers in Drug Discovery
doi 10.3389/fddsv.2026.1919483
Review
Published
Artificial intelligence and computational methods in the Asia-Pacific pharmacovigilance landscape: a systematic review
Gita Kusnadi · Grace Wangge · Arif Perdana
International Journal of Public Health
doi 10.3389/ijph.2026.1610026
Review
Published
Explainable machine learning for predicting treatment outcomes in female genital schistosomiasis and HIV co-morbidity: a narrative review and translational framework
David Chinaecherem Innocent · Rejoicing Chijindum Innocent · Increase Praise Innocent
Frontiers in Tropical Diseases
doi 10.3389/fitd.2026.1894145
Original Research
Published
Behavioral impact of condensed repeated ethanol dosing on withdrawal in adult zebrafish ( Danio rerio )
Rawlie Prince · Tobin Steman · Ethan V. Hagen · Andréa L. Johnson · Yanbo Zhang · Trevor J. Hamilton
Frontiers in Systems Neuroscience
doi 10.3389/fnsys.2026.1924496