Original ResearchPublished 7 October 2026Multi-cohort meta-analysis, single-cell and Mendelian randomization analyses with experimental validation identify RHBDF2 as a shared mediator of ulcerative colitis and blood–brain barrier disruptionJiongjiong Cheng · Aman XuFrontiers in Synaptic Neurosciencedoi 10.3389/fnsyn.2026.1970578