Study ProtocolPublished 9 October 2026Cognitive remediation in schizophrenia: efficacy and role of neuroplasticity in “top-down” and “bottom-up” mechanisms—a randomized, double-blind, treatment-as-usual-controlled study protocolJuan I. Cifuentes · Constanza Orellana · Diego Tello · Cristian Ramírez · Catalina Prieto · Jessica M. Guasti · Rodrigo R. NietoFrontiers in Psychiatrydoi 10.3389/fpsyt.2026.1936475