Original ResearchPublished 12 October 2026Camk2d upregulation is associated with postoperative cognitive dysfunction in aged rats: pharmacological inhibition of CaMKII attenuates hippocampal neuroinflammation and neuronal apoptosisKaihua Wei · Shiwen Fan · Yujia Zhao · Xiaobin Cai · Xinlei Qin · Jingwen Zhai · Liping XieFrontiers in Aging Neurosciencedoi 10.3389/fnagi.2026.1975677