Original ResearchPublished 19 June 2026Efficacy assessment in trials of complex and rare diseases: a comparison between the meta-analytic global statistical test and co-primary analysisSamuel P. Dickson · Abe Durrant · Caleb W. Dayley · Joshua R. Christensen · Craig H. Mallinckrodt · Suzanne B. HendrixFrontiers in Medical Technologydoi 10.3389/fmedt.2026.1819463