Articles | Frontiers

Original Research

Published 12 October 2026

Efficacy and safety of immune checkpoint inhibitor plus bevacizumab-based chemotherapy in advanced or recurrent KRAS -mutant non-squamous NSCLC: the SPIRAL-STONE study

Masaki Ishida · Tadaaki Yamada · Riko Kamada · Makoto Hibino · Masashi Egami · Takayuki Nakano · Tatsuya Imabayashi · Chieko Takumi · Koichi Ishida · Masafumi Takeshita · Ken Masubuchi · Miiru Izumi · Takayo Ota · Shoki Morito · Yusuke Chihara · Soichi Hirai · Shinsuke Shiotsu · Ryo Sawada · Hayato Kawachi · Naoya Nishioka · Masahiro Iwasaku · Koichi Takayama

Frontiers in Immunology

doi 10.3389/fimmu.2026.1875501