Original ResearchPublished 30 September 2026Protoberberine alkaloids berberine and palmatine employ Pf Pgh-1 transporter to enter the digestive vacuole and kill the malaria parasite by inhibiting heme biocrystallizationNekpen Erhunse · Prachi Tomar · Dinkar Sahal · Agam Prasad SinghFrontiers in Drug Discoverydoi 10.3389/fddsv.2026.1949463